Antibody correlates of protection from SARS-CoV-2 reinfection prior to vaccination: A nested case-control within the SIREN study.
Antibody correlates of protection from SARS-CoV-2 reinfection prior to vaccination: A nested case-control within the SIREN study.
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DOI：
10.1016/j.jinf.2022.09.004
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发表时间：
2022-11
影响因子：
28.2
通讯作者：
Hall, Victoria
中科院分区：
文献类型：
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作者：
Atti, Ana;Insalata, Ferdinando;Carr, Edward J.;Otter, Ashley D.;Castillo-Olivares, Javier;Wu, Mary;Harvey, Ruth;Howell, Michael;Chan, Andrew;Lyall, Jonathan;Temperton, Nigel;Cantoni, Diego;da Costa, Kelly;Nadesalingam, Angalee;Taylor-Kerr, Andrew;Hettiarachchi, Nipunadi;Tranquillini, Caio;Hewson, Jacqueline;Cole, Michelle J.;Foulkes, Sarah;Munro, Katie;Monk, Edward J. M.;Milligan, Iain D.;Linley, Ezra;Chand, Meera A.;Brown, Colin S.;Islam, Jasmin;Semper, Amanda;Charlett, Andre;Heeney, Jonathan L.;Beale, Rupert;Zambon, Maria;Hopkins, Susan;Brooks, Tim;Hall, Victoria
研究SARS-CoV-2再感染病例与同期对照之间的血清学差异，以确定抗体相关性，以防止再感染。我们进行了一项病例对照研究，将再感染病例与接种前的单次感染病例进行比较，并按性别、年龄、地区和首次感染时间进行匹配。检测血清样本的抗SARS-CoV-2加标（抗S）、抗SARS-CoV-2核衣壳（抗N）、活病毒微量中和（LV-N）和假病毒微量中和（PV-N）。使用固定效应线性回归分析结果，并拟合到条件Logistic回归模型中。我们确定了23例病例和92例对照。首次感染发生在2020年11月之前;再感染发生在2021年2月之前，即接种疫苗前。抗-S水平，LV-N和PV-N滴度显着降低的情况下，抗-N水平没有发现差异。抗S抗体水平升高与再感染风险降低相关（OR 0·63，CI 0·47-0·85），但与抗N抗体水平无关（OR 0·88，CI 0·73-1·05）。滴度>40与LV-N武汉（OR 0.02，CI 0.001 - 0.31）和LV-N α（OR 0.07，CI 0.009 - 0.62）对再感染的保护作用相关。对于PV-N，滴度>100与对武汉（OR 0.14，CI 0.03 - 0.64）和阿尔法（0.06，CI 0.008 - 0.40）的保护相关。在接种疫苗之前，对SARS-CoV-2再感染的保护与抗S水平、PV-N和LV-N滴度直接相关，但与抗N水平无关。可检测的LV-N滴度足以提供保护，而PV-N滴度>100则需要保护效果。ISRCTN11041050
To investigate serological differences between SARS-CoV-2 reinfection cases and contemporary controls, to identify antibody correlates of protection against reinfection. We performed a case-control study, comparing reinfection cases with singly infected individuals pre-vaccination, matched by gender, age, region and timing of first infection. Serum samples were tested for anti-SARS-CoV-2 spike (anti-S), anti-SARS-CoV-2 nucleocapsid (anti-N), live virus microneutralisation (LV-N) and pseudovirus microneutralisation (PV-N). Results were analysed using fixed effect linear regression and fitted into conditional logistic regression models. We identified 23 cases and 92 controls. First infections occurred before November 2020; reinfections occurred before February 2021, pre-vaccination. Anti-S levels, LV-N and PV-N titres were significantly lower among cases; no difference was found for anti-N levels. Increasing anti-S levels were associated with reduced risk of reinfection (OR 0·63, CI 0·47-0·85), but no association for anti-N levels (OR 0·88, CI 0·73-1·05). Titres >40 were correlated with protection against reinfection for LV-N Wuhan (OR 0·02, CI 0·001–0·31) and LV-N Alpha (OR 0·07, CI 0·009–0·62). For PV-N, titres >100 were associated with protection against Wuhan (OR 0·14, CI 0·03–0·64) and Alpha (0·06, CI 0·008–0·40). Before vaccination, protection against SARS-CoV-2 reinfection was directly correlated with anti-S levels, PV-N and LV-N titres, but not with anti-N levels. Detectable LV-N titres were sufficient for protection, whilst PV-N titres >100 were required for a protective effect. ISRCTN11041050
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SARS-COV-2的抗体防止在2020年9月和10月10日在养老院爆发期间再感染。
DOI：
10.2807/1560-7917.es.2021.26.5.2100092
发表时间：
2021-03
期刊：
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin
影响因子：
--
作者：
Jeffery-Smith A;Iyanger N;Williams SV;Chow JY;Aiano F;Hoschler K;Lackenby A;Ellis J;Platt S;Miah S;Brown K;Amirthalingam G;Patel M;Ramsay ME;Gopal R;Charlett A;Ladhani SN;Zambon M
通讯作者：
Zambon M
DOI：
10.1016/s2666-5247(21)00157-9
发表时间：
2021-09
期刊：
The Lancet. Microbe
影响因子：
--
作者：
Nadesalingam A;Cantoni D;Wells DA;Aguinam ET;Ferrari M;Smith P;Chan A;Carnell G;Ohlendorf L;Einhauser S;George C;Wagner R;Temperton N;Castillo-Olivares J;Baxendale H;Heeney JL;HICC consortium
通讯作者：
HICC consortium
影响因子：
5.6
作者：
Veronica F;Anne R;Christopher B;Kenneth C;Jon R
通讯作者：
Jon R
影响因子：
9.4
作者：
Addetia A;Crawford KHD;Dingens A;Zhu H;Roychoudhury P;Huang ML;Jerome KR;Bloom JD;Greninger AL
通讯作者：
Greninger AL
影响因子：
15.8
作者：
通讯作者：
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