Decreased mismatch negativity and elevated frontal-lateral connectivity in first-episode psychosis.
Decreased mismatch negativity and elevated frontal-lateral connectivity in first-episode psychosis.
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DOI：
10.1016/j.jpsychires.2021.09.034
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发表时间：
2021-12
影响因子：
4.8
通讯作者：
Öngür D
中科院分区：
文献类型：
--
作者：
Yüksel M;Murphy M;Rippe J;Leicht G;Öngür D
错配负波降低（MMN）是精神病性障碍的拟议生物标志物。然而，在首次发病人群中，这种效应的程度似乎有所减弱。此外，不匹配负波振幅如何与该人群的大脑连接性相关尚不清楚。在这项研究中，我们使用高密度脑电图记录持续时间偏离MMN从22例首发精神病（FEP）和23名年龄匹配的对照（HC）。与过去的工作相一致，我们发现减少MMN振幅FEP在大面积的额部头皮。我们还发现枕部头皮的潜伏期缩短。MMN波幅与抗精神病药物剂量呈负相关。我们使用格兰杰因果关系，以探讨在MMN额叶，中线，左，右头皮之间的方向连接，发现减少连接FEP相比HC和以下偏离刺激相比，标准刺激。FEP参与者从标准到偏差刺激的连接性下降较小，混乱症状更严重。另一方面，从前面的头皮异常刺激后的连接相对保留在FEP相比，控制。我们的研究结果表明，自下而上和自上而下的知觉加工的相对不平衡存在于精神障碍的早期阶段。
Decreased mismatch negativity (MMN) is a proposed biomarker for psychotic disorders. However, the magnitude of the effect appears to be attenuated in first-episode populations. Furthermore, how mismatch negativity amplitudes are related to brain connectivity in this population is unclear. In this study, we used high-density EEG to record duration-deviant MMN from 22 patients with first-episode psychosis (FEP) and 23 age-matched controls (HC). Consistent with past work, we found decreased MMN amplitude in FEP over a large area of the frontal scalp. We also found decreased latency over the occipital scalp. MMN amplitude was negatively correlated with antipsychotic dose. We used Granger causality to investigate directional connectivity between frontal, midline, left, and right scalp during MMN and found reduced connectivity in FEP compared to HC and following deviant stimuli compared to standard stimuli. FEP participants with smaller decreases in connectivity from standard to deviant stimuli had worse disorganization symptoms. On the other hand, connectivity from the front of the scalp following deviant stimuli was relatively preserved in FEP compared to controls. Our results suggest that a relative imbalance of bottom-up and top-down perceptual processing is present in the early stages of psychotic disorders.
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