Mismatch negativity latency and cognitive function in schizophrenia.
Mismatch negativity latency and cognitive function in schizophrenia.
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DOI：
10.1371/journal.pone.0084536
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Müller BW
中科院分区：
文献类型：
--
作者：
Kärgel C;Sartory G;Kariofillis D;Wiltfang J;Müller BW
错配负波（MMN）是一种对早期听觉异常检测敏感的事件相关电位（ERP），已被证明在精神分裂症患者中会降低。此外，MMN振幅减少持续时间偏差音被发现与功能的结果，特别是神经心理（工作记忆和言语领域）和心理社会措施。虽然MMN振幅被认为与早期感觉处理的缺陷相关，但MMN潜伏期的功能意义至今仍不清楚。本研究旨在探讨精神分裂症患者MMN与神经心理功能的关系。40名精神分裂症患者和16名健康对照者进行了被动oddball范式（2400双耳音; 88%标准[1 kHz，80 db，80 ms]，11%频率偏差[1.2 kHz]，11%持续时间偏差[40 ms]）和神经心理学测试电池。对患者的临床症状进行评估。与健康对照组相比，精神分裂症患者表现出减少的MMN振幅和较短的MMN潜伏期，这两个偏差，以及受损的神经心理测试性能。阳性症状的严重程度与MMN振幅下降持续时间偏差有关。此外，增强的言语记忆表现与患者对频率偏差的MMN潜伏期延长有关。本研究证实了以前的结果，减少MMN振幅及其与精神分裂症患者的阳性症状。这两个，一个较短的潜伏期的持续时间和频率偏差和后者与患者的言语记忆的关系的研究结果，强调精神分裂症的早期听觉辨别处理的时间方面的相关性。
The Mismatch Negativity (MMN) is an event-related potential (ERP) sensitive to early auditory deviance detection and has been shown to be reduced in schizophrenia patients. Moreover, MMN amplitude reduction to duration deviant tones was found to be related to functional outcomes particularly, to neuropsychological (working memory and verbal domains) and psychosocial measures. While MMN amplitude is thought to be correlated with deficits of early sensory processing, the functional significance of MMN latency remains unclear so far. The present study focused on the investigation of MMN in relation to neuropsychological function in schizophrenia. Forty schizophrenia patients and 16 healthy controls underwent a passive oddball paradigm (2400 binaural tones; 88% standards [1 kHz, 80 db, 80 ms], 11% frequency deviants [1.2 kHz], 11% duration deviants [40 ms]) and a neuropsychological test-battery. Patients were assessed with regard to clinical symptoms. Compared to healthy controls schizophrenia patients showed diminished MMN amplitude and shorter MMN latency to both deviants as well as an impaired neuropsychological test performance. Severity of positive symptoms was related to decreased MMN amplitude to duration deviants. Furthermore, enhanced verbal memory performance was associated with prolonged MMN latency to frequency deviants in patients. The present study corroborates previous results of a diminished MMN amplitude and its association with positive symptoms in schizophrenia patients. Both, the findings of a shorter latency to duration and frequency deviants and the relationship of the latter with verbal memory in patients, emphasize the relevance of the temporal aspect of early auditory discrimination processing in schizophrenia.
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影响因子：
3
作者：
Fisher, Derek J.;Grant, Bryan;Knott, Verner J.
通讯作者：
Knott, Verner J.
影响因子：
5.7
作者：
Doeller, CF;Opitz, B;Schröger, E
通讯作者：
Schröger, E
影响因子：
2.9
作者：
Dulude, Louise;Labelle, Alain;Knott, Verner J.
通讯作者：
Knott, Verner J.
DOI：
10.1016/j.clinph.2008.11.029
发表时间：
2009-03
期刊：
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
影响因子：
--
作者：
Garrido MI;Kilner JM;Stephan KE;Friston KJ
通讯作者：
Friston KJ
影响因子：
3
作者：
Baldeweg, T;Wong, D;Stephan, KE
通讯作者：
Stephan, KE