Spatial and temporal coordination of bone marrow-derived cell activity during arteriogenesis: regulation of the endogenous response and therapeutic implications.
Spatial and temporal coordination of bone marrow-derived cell activity during arteriogenesis: regulation of the endogenous response and therapeutic implications.
复制标题
DOI：
10.1111/j.1549-8719.2010.00051.x
复制
发表时间：
2010-11
期刊：
影响因子：
--
通讯作者：
Price RJ
中科院分区：
文献类型：
--
作者：
Meisner JK;Price RJ
动脉闭塞性疾病（AOD）是发达国家发病率和死亡率的主要原因，因此迫切需要有效的治疗方法来阻止疾病进展。尽管动物和小规模的人体动脉发生治疗研究取得了成功，但这种治疗AOD的有希望的概念在大规模临床试验中却产生了令人失望的结果。缺乏成功翻译的一个原因是内源性动脉发生高度依赖于对骨髓来源细胞（bmmc）和血管细胞之间的事件序列和相互作用知之甚少，这使得设计有效的治疗方法变得困难。我们认为，这个过程遵循一个复杂的、有序的事件序列，在特定的时间和地点招募了多个特定的BMC群体。在这里，我们提出了证据表明从中性粒细胞和肥大细胞到祖细胞的多个BMC群体的作用，并提出了这些细胞群体在动脉发生过程中如何以及在何处适应事件序列。这些不同BMC群体的破坏会损害特定患者群体的动脉形成过程。我们建议，对动脉形成如何作为一个系统发挥作用的更好理解可以揭示个体BMC群体和功能，这些群体和功能可以靶向克服侧支血管发育中的特定损伤。
Arterial occlusive disease (AOD) is the leading cause of morbidity and mortality through the developed world, which creates a significant need for effective therapies to halt disease progression. Despite success of animal and small-scale human therapeutic arteriogenesis studies, this promising concept for treating AOD has yielded largely disappointing results in large-scale clinical trials. One reason for this lack of successful translation is that endogenous arteriogenesis is highly dependent on a poorly understood sequence of events and interactions between bone marrow derived cells (BMCs) and vascular cells, which makes designing effective therapies difficult. We contend that the process follows a complex, ordered sequence of events with multiple, specific BMC populations recruited at specific times and locations. Here we present the evidence suggesting roles for multiple BMC populations from neutrophils and mast cells to progenitor cells and propose how and where these cell populations fit within the sequence of events during arteriogenesis. Disruptions in these various BMC populations can impair the arteriogenesis process in patterns that characterize specific patient populations. We propose that an improved understanding of how arteriogenesis functions as a system can reveal individual BMC populations and functions that can be targeted for overcoming particular impairments in collateral vessel development.
登录
查看更多内容
影响因子：
56.9
作者：
Asahara, T;Murohara, T;Isner, JM
通讯作者：
Isner, JM
影响因子：
4.4
作者：
El-Shazly, A;Berger, P;Tunon-de-Lara, JM
通讯作者：
Tunon-de-Lara, JM
DOI：
10.1152/ajpheart.00478.2002
发表时间：
2003-01-01
影响因子：
4.8
作者：
Cai, WJ;Koltai, S;Schaper, J
通讯作者：
Schaper, J
影响因子：
20.1
作者：
Deindl, E;Buschmann, I;Schaper, W
通讯作者：
Schaper, W
影响因子：
5
作者：
Chalothorn D;Faber JE
通讯作者：
Faber JE