Smoking status and pain level among head and neck cancer patients.
Smoking status and pain level among head and neck cancer patients.
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DOI：
10.1016/j.jpain.2009.09.006
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发表时间：
2010-06
期刊：
影响因子：
--
通讯作者：
Mendenhall WM
中科院分区：
文献类型：
--
作者：
Logan HL;Fillingim RB;Bartoshuk LM;Sandow P;Tomar SL;Werning JW;Mendenhall WM
吸烟是上呼吸消化道癌症的一个危险因素，即使在诊断后，复发率也很高。尼古丁是烟草中的主要产品，是一种复杂的药物，具有多种特性，包括镇痛特性。该研究的目的是在最近诊断为上呼吸消化道癌症的患者中检查吸烟状态下的疼痛水平，这些患者尚未接受任何治疗，包括放射，手术或化疗。从佛罗里达大学的诊所招募了112名新诊断的头颈癌患者（78名男性和34名女性）的便利样本。吸烟率为：32%从不吸烟，34%曾吸烟，34%目前吸烟。在目前的吸烟者中，62%的人表示计划在未来3个月内戒烟，38%的人在过去5年内尝试戒烟超过3次。目前吸烟者报告的全身（感觉和情感）和口腔疼痛水平（自发性和功能性）以及疼痛相关干扰高于从不吸烟者和既往吸烟者（所有F>8）。和p <.0001）。此外，目前吸烟者报告疼痛的干扰显著更大（F2，73=10.5 p<.0001）。这项研究强调了了解继续吸烟的癌症患者自我报告疼痛的重要性。当疼痛加剧时，吸烟者可能会有动机使用烟草作为减轻疼痛的手段，这反过来又会加强吸烟行为。戒烟计划应包括疼痛管理作为治疗的一部分。
Smoking is a risk factor for cancer of the upper aerodigestive tract with recidivism rates high even after diagnosis. Nicotine, a major product in tobacco, is a complex drug with multiple characteristics including analalgesic properties. The goal of the study was to examine pain levels in the context of smoking status among patients recently diagnosed with cancer of the upper aerodigestive tract who have not yet received any treatment including radiation, surgery, or chemotherapy. A convenience sample of 112 newly diagnosed head and neck cancer patients (78 men and 34 women) were recruited from clinics at the University of Florida. Smoking rates were: 32% never smoked, 34% former smokers, 34% current smokers. Among current smokers, 62% reported plans to quit in the next 3 months and 38% had tried to quit more than three times in the past 5 years. Current smokers reported higher general (sensory and affective) and oral pain levels (spontaneous and functional) and pain-related interference than did never and former smokers (all F’s >8. and p’s <.0001) even after controlling for stage of diagnosis. In addition, current smokers reported significantly greater interference from the pain (F2,73=10.5 p<.0001). This study highlights the importance of understanding self-reported pain in cancer patients who continue to smoke. When pain is elevated, smokers may be motivated to use tobacco as a means of reducing pain, which in turn reinforces smoking behavior. Tobacco cessation programs should include pain management as a component of treatment.
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