Novel insights of dietary polyphenols and obesity.
Novel insights of dietary polyphenols and obesity.
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DOI：
10.1016/j.jnutbio.2013.09.001
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发表时间：
2014-01
影响因子：
5.6
通讯作者：
Shen, Chwan-Li
中科院分区：
文献类型：
--
作者：
Wang, Shu;Moustaid-Moussa, Naima;Chen, Lixia;Mo, Huanbiao;Shastri, Anuradha;Su, Rui;Bapat, Priyanka;Kwun, InSook;Shen, Chwan-Li
在过去的三十年里，无论是在美国还是在世界范围内，肥胖的患病率都在稳步上升。最近的研究表明，膳食多酚在预防肥胖和肥胖相关的慢性疾病中的作用。在这里，我们评估了常食用的多酚，包括绿茶儿茶素和表没食子儿茶素没食子酸酯，白藜芦醇和姜黄素，对肥胖和肥胖相关炎症的影响。细胞研究表明，这些膳食多酚降低脂肪细胞的活力和前脂肪细胞的增殖，抑制脂肪细胞分化和甘油三酯的积累，刺激脂肪分解和脂肪酸β氧化，并减轻炎症。同时，多酚调节信号通路，包括amp激活的蛋白激酶、过氧化物酶体增殖体激活受体γ、CCAAT/增强子结合蛋白α、PPAR γ激活因子1- α、sirtuin 1、固醇调节元件结合蛋白1c、解偶联蛋白1和2，以及调节脂肪生成、抗氧化和抗炎反应的核因子kappa B。动物研究有力地表明，本综述中描述的常食用的多酚对肥胖有显著的影响，通过增强能量消耗和脂肪利用以及调节葡萄糖止血来降低体重、脂肪量和甘油三酯。在这一领域进行了有限的人体研究，并且关于饮食多酚的抗肥胖作用的研究并不一致，可能是由于不同的研究设计和长度，受试者之间的差异（年龄，性别，种族），所使用的饮食多酚的化学形式以及其他减肥剂等混杂因素。未来的随机对照试验有必要调和这些多酚的临床前疗效和不确定的临床结果之间的差异。
Prevalence of obesity has steadily increased over the past three decades both in the United States and worldwide. Recent studies have shown the role of dietary polyphenols in the prevention of obesity and obesity-related chronic diseases. Here we evaluated the impact of commonly consumed polyphenols, including green tea catechins and epigallocatechin gallates, resveratrol, and curcumin, on obesity and obesity-related-inflammation. Cellular studies demonstrated that these dietary polyphenols reduce viability of adipocytes and proliferation of preadipocytes, suppress adipocyte differentiation and triglyceride accumulation, stimulate lipolysis and fatty acid β-oxidation, and reduce inflammation. Concomitantly, the polyphenols modulate signaling pathways including the AMP-activated protein kinase, peroxisome proliferator activated receptor γ, CCAAT/enhancer binding protein α, PPAR gamma activator 1-alpha, sirtuin 1, sterol regulatory element binding protein-1c, uncoupling proteins 1 and 2, and nuclear factor kappa B that regulate adipogenesis, antioxidant and anti-inflammatory responses. Animal studies strongly suggest that commonly consumed polyphenols described in this review have a pronounced effect on obesity as shown by lower body weight, fat mass, and triglycerides through enhancing energy expenditure and fat utilization, and modulating glucose hemostasis. Limited human studies have been conducted in this area, and are inconsistent about the anti-obesity impact of dietary polyphenols, probably due to the various study designs and lengths, variation among subjects (age, gender, ethnicity), chemical forms of the dietary polyphenols used and confounding factors such as other weight reducing agents. Future randomized controlled trials are warranted to reconcile the discrepancies between preclinical efficacies and inconclusive clinic outcomes of these polyphenols.
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DOI：
10.1093/jn/138.9.1677
发表时间：
2008-09
期刊：
The Journal of nutrition
影响因子：
--
作者：
Bose M;Lambert JD;Ju J;Reuhl KR;Shapses SA;Yang CS
通讯作者：
Yang CS
影响因子：
6.9
作者：
Alvehus, Malin;Buren, Jonas;Olsson, Tommy
通讯作者：
Olsson, Tommy
影响因子：
3
作者：
Beher, Dirk;Wu, John;Wang, Minghan
通讯作者：
Wang, Minghan
影响因子：
5.3
作者：
Boscá, AR;Soler, A;Miquel, J
通讯作者：
Miquel, J
影响因子：
--
作者：
Abramson, JL;Vaccarino, V
通讯作者：
Vaccarino, V