Assessing salivary C-reactive protein: longitudinal associations with systemic inflammation and cardiovascular disease risk in women exposed to intimate partner violence.
Assessing salivary C-reactive protein: longitudinal associations with systemic inflammation and cardiovascular disease risk in women exposed to intimate partner violence.
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DOI：
10.1016/j.bbi.2012.01.019
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发表时间：
2012-05
影响因子：
15.1
通讯作者：
Woods, Stephanie J.
中科院分区：
文献类型：
--
作者：
Out, Dorothee;Hall, Rosalie J.;Granger, Douglas A.;Page, Gayle G.;Woods, Stephanie J.
本研究评估了唾液中C反应蛋白（CRP）水平的个体差异，横断面和前瞻性，与全身炎症和心血管疾病（CVD）的风险。血浆和唾液样本，后来测定CRP，收集多次从一个种族多样化的妇女群体寻求帮助，从家庭暴力危机庇护所机构（N = 107;平均年龄在研究开始= 34岁）。血浆和唾液CRP水平在横断面和两年中中度相关。有迹象表明，唾液CRP水平平均在早上比晚上高。较高的唾液和血浆CRP水平与较高的体重指数相关，但在吸烟和不吸烟的女性之间没有差异。唾液CRP可靠地区分高和低水平的血浆CRP，使用临床相关的截止点3毫克/升，由美国心脏协会推荐。结果建立在一个新兴的文献表明，在特定条件下，唾液中的CRP水平可能反映低度炎症，并有可能作为CVD风险状态的屏幕。
This study evaluated individual differences in levels of C-reactive protein (CRP) measured in saliva, cross-sectionally and prospectively, in relation to systemic inflammation and risk for cardiovascular disease (CVD). Plasma and saliva samples, later assayed for CRP, were collected multiple times from an ethnically diverse group of women seeking help from domestic violence crisis shelters-agencies (N = 107; mean age at study start = 34 years). Plasma and saliva CRP levels were moderately associated cross-sectionally and across two years. There were indications that saliva CRP levels were, on average, higher in the morning than evening. Higher levels of saliva and plasma CRP were associated with a higher body mass index, but did not differ between women who did and did not smoke. Salivary CRP reliably discriminated between high and low levels of plasma CRP, using a clinically relevant cutoff point of 3 mg/L, recommended by the American Heart Association. Results build upon an emerging literature suggesting that under specific conditions levels of CRP in saliva may reflect low-grade inflammation and have the potential to serve as a screen for CVD risk status.
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影响因子：
2.2
作者：
Miller CS;Foley JD;Bailey AL;Campell CL;Humphries RL;Christodoulides N;Floriano PN;Simmons G;Bhagwandin B;Jacobson JW;Redding SW;Ebersole JL;McDevitt JT
通讯作者：
McDevitt JT
影响因子：
168.9
作者：
Ellsberg, Mary;Jansen, Henrica A. F. M.;Garcia-Moreno, Claudia
通讯作者：
Garcia-Moreno, Claudia
影响因子：
4.3
作者：
Noack, B;Genco, RJ;De Nardin, E
通讯作者：
De Nardin, E
影响因子：
--
作者：
Campbell, J;Jones, AS;Wynne, C
通讯作者：
Wynne, C
影响因子：
15.1
作者：
Ouellet-Morin, I.;Danese, A.;Arseneault, L.
通讯作者：
Arseneault, L.