EEG sharp waves and sparse ensemble unit activity in the macaque hippocampus.
EEG sharp waves and sparse ensemble unit activity in the macaque hippocampus.
复制标题
猕猴海马的脑电图锐波和稀疏的集合单元活动。
DOI：
10.1152/jn.00401.2007
复制
发表时间：
2007
影响因子：
2.5
通讯作者：
Barnes,CarolA
中科院分区：
文献类型：
--
作者：
Skaggs,WilliamE;McNaughton,BruceL;Permenter,Michele;Archibeque,Matthew;Vogt,Julie;Amaral,DavidG;Barnes,CarolA
神经单位活动和脑电图记录从下颞区的三个恒河猴长期植入“超驱动器”持有12个单独可移动的四极。每只猴子的记录都持续了103个月，同时电极在海马体和邻近结构中以小的增量移动。记录后，对猴子进行尸检，将大脑切片并进行Nissl染色，以识别单个电极轨迹。结果表明，海马锥体细胞是“复杂的棘波细胞”，以10.3 Hz的总体平均频率放电，棘波序列由长时间的沉默和间歇的活动组成。结果还证实，猴海马EEG显示由高频“涟漪”振荡（约110 Hz）和持续数百毫秒的大的慢波EEG偏转组成的“尖波”事件。证据表明，猴尖波可能主要产生于CA 1区，尖波与不活动/困倦或睡眠行为状态相关，这也与海马锥体细胞活动增加和海马EEG振幅增加相关。灵长类动物海马神经元的合奏的初步研究结果是一致的，与以前的研究在啮齿动物和海马记忆功能的理论和模型的基础上开发的大鼠数据可能适用于广泛的哺乳动物物种的假设是一致的。
Neural unit activity and EEGs were recorded from inferior temporal regions of three rhesus macaques chronically implanted with “hyperdrives” holding 12 individually movable tetrodes. Recordings were made from each monkey over a period of ∼3 mo, while the electrodes were moved by small increments through the hippocampus and neighboring structures. After recording, the monkeys were necropsied, and the brains were sectioned and Nissl-stained, permitting identification of individual electrode tracks. The results establish that hippocampal pyramidal cells are “complex spike cells,” firing at overall average rates of ∼0.3 Hz, with spike trains consisting of long periods of silence interspersed with bursts of activity. The results also establish that the monkey hippocampal EEG shows “sharp wave” events consisting of a high-frequency “ripple” oscillation (∼110 Hz) together with a large slow-wave EEG deflection lasting several hundred milliseconds. The evidence suggests that monkey sharp waves are probably generated mainly in the CA1 region and that sharp waves are associated with an inactive/drowsy-or-sleeping behavioral state, which is also associated with increased hippocampal pyramidal cell activity and increased hippocampal EEG amplitude. The results of this initial study of ensembles of primate hippocampal neurons are consistent with previous studies in rodents and consistent with the hypothesis that theories and models of hippocampal memory function developed on the basis of rat data may be applicable to a wide range of mammalian species.
登录
查看更多内容
影响因子：
56.9
作者：
WILSON, MA;MCNAUGHTON, BL
通讯作者：
MCNAUGHTON, BL
Hebb-Marr 网络和空间行为的神经生物学表征。
DOI：
--
发表时间：
1990
期刊：
影响因子：
--
作者：
B. McNaughton;L. Nadel
通讯作者：
L. Nadel
TraceLink：健忘症和记忆巩固模型
影响因子：
3.5
作者：
J. Murre
通讯作者：
J. Murre
DOI：
10.1098/rstb.2001.0948
发表时间：
2001-09-29
影响因子：
6.3
作者：
Burgess, N;Becker, S;O'Keefe, J
通讯作者：
O'Keefe, J
影响因子：
5.3
作者：
FOX, SE;RANCK, JB
通讯作者：
RANCK, JB