Analysis of Changes in Cancer-Related Fatigue of Breast Cancer Patients Receiving an Integrative Medicine Program.
Analysis of Changes in Cancer-Related Fatigue of Breast Cancer Patients Receiving an Integrative Medicine Program.
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DOI：
10.1177/1534735420963780
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发表时间：
2020-01
影响因子：
2.9
通讯作者：
Oei SL
中科院分区：
文献类型：
--
作者：
Schad F;Thronicke A;von Trott P;Oei SL
癌症相关性疲乏（CRF）在乳腺癌患者中经常发生。本真实世界研究的目的是分析接受中西医结合治疗的乳腺癌患者CRF的纵向变化，其中包括非药物干预（NPIs）和槲寄生的应用。(VA)萃取物所有数据均收集自德国认证乳腺癌中心Havelhöhe（GKH）网络肿瘤学的临床登记。原发性乳腺癌患者，在首次诊断时接受综合NPI治疗，包括艺术和运动疗法，护理干预和教育成分，在住院期间，并在首次诊断时和12个月后回答德国癌症疲劳量表（CFS-D）问卷。使用R软件，考虑到接受的治疗方案和人口统计学变量，通过调整的多变量回归分析分析NPI和CFS-D变化之间的关联。评估了231名所有肿瘤阶段的女性乳腺癌患者。虽然化疗表现出显着的严重恶化，附加VA应用程序似乎部分减轻这种损害的CRF。对所有NPI进行的36项独立的多变量回归分析显示，CFS-D改善与护理敷布干预（6分变化; P = .0002; R² = 28%）或精心咨询和生活回顾（ECLR）（4分变化; P = .0002; R² = 25%）之间存在显著相关性。乳腺癌患者受益于以医院为基础的综合医学计划。为了减轻肿瘤治疗期间的疲劳症状，未来应扩展这一概念。
Cancer-related fatigue (CRF) occurs frequently in breast cancer patients. The aim of this real-world study was to analyze the longitudinal changes of CRF in breast cancer patients receiving an integrative medicine program, which includes the application of non-pharmacological interventions (NPIs) and Viscum album L. (VA) extracts. All data were collected from the clinical register of the Network Oncology of a German certified breast cancer center of the Gemeinschaftskrankenhaus Havelhöhe (GKH). Primary breast cancer patients, treated upon initial diagnosis with integrated NPIs, comprising art and exercise therapy, nursing interventions, and educational components, during their hospital stay, and who had answered the German Cancer-Fatigue Scale (CFS-D) questionnaire at first diagnosis and 12 months later, were included. The associations between NPIs and CFS-D changes were analyzed with adjusted multivariable regression analyses, considering received treatment regimens and demographic variables, using the software R. 231 female breast cancer patients of all tumor stages were evaluated. While chemotherapy exhibited significant severe deterioration, add-on VA applications seem to partially mitigate this impairment on CRF. 36 separate multivariable regression analyses for all NPIs showed that in particular significant associations between CFS-D improvements and the interventions nursing compresses (6 point change; P = .0002; R² = 28%) or elaborate consultations and life review (ECLR) (4 point change; P = .0002; R² = 25%) were observed. Breast cancer patients benefit from a hospital-based integrative medicine program. To alleviate fatigue symptoms during oncological therapy, an expansion of this concept should be developed in the future.
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影响因子：
3.8
作者：
Meneses-Echávez JF;González-Jiménez E;Ramírez-Vélez R
通讯作者：
Ramírez-Vélez R
影响因子：
--
作者：
Kienle GS;Albonico HU;Baars E;Hamre HJ;Zimmermann P;Kiene H
通讯作者：
Kiene H
影响因子：
4.2
作者：
Donovan, Kristine A.;Small, Brent J.;Jacobsen, Paul B.
通讯作者：
Jacobsen, Paul B.
影响因子：
3.9
作者：
Fabi, Alessandra;Falcicchio, Chiara;Pugliese, Patrizia
通讯作者：
Pugliese, Patrizia
影响因子：
1.1
作者：
Mitchell, Sandra A.;Hoffman, Amy J.;Weisbrod, Breanna L.
通讯作者：
Weisbrod, Breanna L.