Intra-articular microparticles for drug delivery to the TMJ.
Intra-articular microparticles for drug delivery to the TMJ.
复制标题
DOI：
10.1177/0022034510375286
复制
发表时间：
2010-10
影响因子：
7.6
通讯作者：
Kramer PR
中科院分区：
文献类型：
--
作者：
Mountziaris PM;Sing DC;Mikos AG;Kramer PR
本研究描述了关节内聚（DL-乳酸-羟基乙酸共聚物）（PLGA）微粒（MP）制剂在大鼠颞下颌关节（TMJ）中的体内生物相容性。据我们所知，这是第一个关节内微粒为基础的药物输送系统的颞下颌关节。PLGA MP浓度对大鼠TMJ功能的影响通过计算机化膳食模式分析进行量化;在这种非侵入性技术中，使用计算机监测的颗粒喂食器记录先前验证的TMJ疼痛标志物（特别是进餐时间和摄食量）。与未接受注射的对照组相比，双侧关节内注射15、30或50 mg/mL PLGA MP对6天的进餐时间或食物摄入量没有影响。组织学分析表明，MP保留在滑膜衬里内。这些发现表明，本文所述的PLGA MP是生物相容的，并且适合于关节内递送至大鼠TMJ，这一发现对TMJ治疗的改进具有重要意义。
This study describes the in vivo biocompatibility of intra-articular poly(DL-lactic-co-glycolic acid) (PLGA) microparticle (MP) formulations in the rat temporomandibular joint (TMJ). To our knowledge, this is the first intra-articular microparticle-based drug delivery system for the TMJ. The impact of PLGA MP concentration on rat TMJ function was quantified via computerized meal pattern analysis; in this non-invasive technique, previously validated markers of TMJ pain (specifically, meal duration and food intake) were recorded using computer-monitored pellet feeders. Bilateral intra-articular injection of 15, 30, or 50 mg/mL PLGA MPs had no impact on meal duration or food intake over six days, compared to controls that did not receive injections. Histological analysis showed that the MPs were retained within the synovial lining. These findings indicate that the PLGA MPs described herein are biocompatible and suitable for intra-articular delivery to the rat TMJ, a finding that has significant implications for the improvement of TMJ therapeutics.
登录
查看更多内容
影响因子：
3.6
作者：
Kerins, CA;Carlson, DS;Bellinger, LL
通讯作者：
Bellinger, LL
影响因子：
4.8
作者：
Mountziaris, Paschalia M.;Kramer, Phillip R.;Mikos, Antonios G.
通讯作者：
Mikos, Antonios G.
影响因子：
2.9
作者：
Bellinger, Larry L.;Spears, Robert;Kramer, Phillip R.
通讯作者：
Kramer, Phillip R.
影响因子：
3
作者：
Ekuni, D;Firth, JD;Putnins, EE
通讯作者：
Putnins, EE
影响因子：
9.7
作者：
Patel, Zarana S.;Yamamoto, Masaya;Mikos, Antonios G.
通讯作者：
Mikos, Antonios G.