Emerging intra-articular drug delivery systems for the temporomandibular joint.
Emerging intra-articular drug delivery systems for the temporomandibular joint.
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DOI：
10.1016/j.ymeth.2008.09.001
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发表时间：
2009-02
期刊：
影响因子：
4.8
通讯作者：
Mikos, Antonios G.
中科院分区：
文献类型：
--
作者：
Mountziaris, Paschalia M.;Kramer, Phillip R.;Mikos, Antonios G.
关键词：
颞下颌关节（TMJ）疾病是一组异质性疾病，导致进行性关节退化，导致慢性疼痛和生活质量下降。有效减轻疼痛和恢复颞下颌关节功能仍然是尚未解决的挑战。关节内注射皮质类固醇和透明质酸目前用于治疗慢性疼痛，但这些方法需要多次注射，增加了医源性关节损伤和其他并发症的风险。颞下颌关节组织工程是一个新兴的小领域，旨在通过诱导关节组织再生的新策略来减少疼痛和残疾。开发关节内持续释放生长因子和其他促再生信号的方法对于TMJ组织工程策略的成功至关重要。这篇综述讨论了关节内药物输送到TMJ的方法，以及新兴的注射控释系统，有可能改善TMJ药物输送，以鼓励进一步研究开发缓释系统，用于长期疼痛管理和增强TMJ再生的组织工程策略。
Temporomandibular joint (TMJ) disorders are a heterogeneous group of diseases that cause progressive joint degeneration leading to chronic pain and reduced quality of life. Both effective pain reduction and restoration of TMJ function remain unmet challenges. Intra-articular injections of corticosteroids and hyaluronic acid are currently used to treat chronic pain, but these methods require multiple injections that increase the risk of iatrogenic joint damage and other complications. The small and emerging field of TMJ tissue engineering aims to reduce pain and disability through novel strategies that induce joint tissue regeneration. Development of methods for sustained, intra-articular release of growth factors and other pro-regenerative signals will be critical for the success of TMJ tissue engineering strategies. This review discusses methods of intra-articular drug delivery to the TMJ, as well as emerging injectable controlled release systems with potential to improve TMJ drug delivery, to encourage further research in the development of sustained release systems for both long-term pain management and to enhance tissue engineering strategies for TMJ regeneration.
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