Impacts of gut bacteria on human health and diseases.

Impacts of gut bacteria on human health and diseases.
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肠道细菌对人类健康和疾病的影响

DOI:
10.3390/ijms16047493
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发表时间:
2015-04-02
影响因子:
5.6
通讯作者:
Li HB
Li HB
中科院分区:
生物学2区
文献类型:
--
作者:
Zhang YJ;Li S;Gan RY;Zhou T;Xu DP;Li HB

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肠道细菌是人体肠道微生物群生态系统的重要组成部分,肠道内定植的微生物数量为1014种,是人体细胞数量的10倍。肠道细菌在人体健康中发挥着重要的作用,如提供必需的营养物质,合成维生素K,帮助纤维素的消化,促进血管生成和肠神经功能。然而,当肠道生态系统因抗生素的使用、疾病、压力、衰老、不良的饮食习惯和生活方式而发生异常变化时,它们也可能由于其组成的变化而具有潜在的危害。肠道菌群失调会导致许多慢性疾病,如炎症性肠病、肥胖、癌症和自闭症。本文就肠道细菌在人类健康和疾病中的作用及其潜在机制进行综述和讨论。
Gut bacteria are an important component of the microbiota ecosystem in the human gut, which is colonized by 1014 microbes, ten times more than the human cells. Gut bacteria play an important role in human health, such as supplying essential nutrients, synthesizing vitamin K, aiding in the digestion of cellulose, and promoting angiogenesis and enteric nerve function. However, they can also be potentially harmful due to the change of their composition when the gut ecosystem undergoes abnormal changes in the light of the use of antibiotics, illness, stress, aging, bad dietary habits, and lifestyle. Dysbiosis of the gut bacteria communities can cause many chronic diseases, such as inflammatory bowel disease, obesity, cancer, and autism. This review summarizes and discusses the roles and potential mechanisms of gut bacteria in human health and diseases.
DOI: 10.1002/emmm.201100159
发表时间: 2011-09
影响因子: 11.1
作者:
Amar, Jacques;Chabo, Chantal;Waget, Aurelie;Klopp, Pascale;Vachoux, Christelle;Bermudez-Humaran, Luis G.;Smirnova, Natalia;Berge, Mathieu;Sulpice, Thierry;Lahtinen, Sampo;Ouwehand, Arthur;Langella, Philippe;Rautonen, Nina;Sansonetti, Philippe J.;Burcelin, Remy
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DOI: 10.1371/journal.pone.0007125
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期刊: PloS one
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发表时间: 2011-03-16
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DOI: 10.1128/aem.71.10.6077-6085.2005
发表时间: 2005-10-01
影响因子: 4.4
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Clavel, T;Henderson, G;Blaut, M
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