Heart rate variability and HbA1c predict plasma interleukin-6 response to psychosocial stress challenge in trauma-exposed women with type 2 diabetes.
Heart rate variability and HbA1c predict plasma interleukin-6 response to psychosocial stress challenge in trauma-exposed women with type 2 diabetes.
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DOI：
10.1016/j.bbih.2021.100400
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发表时间：
2022-03
期刊：
影响因子：
--
通讯作者：
Seligowski AV
中科院分区：
文献类型：
--
作者：
Merker JB;Dixon HD;Gluck R;Kim YJ;Powers A;Schwartz AC;Jovanovic T;Umpierrez G;Ressler KJ;Michopoulos V;Pace TWW;Gillespie CF;Seligowski AV
2型糖尿病（T2DM）是美国一个主要的公共卫生问题。虽然已知心血管自主功能、血糖控制和炎症在2型糖尿病中起作用，但这些变量之间的相互作用在很大程度上仍未被探索，特别是在应激背景下。为了解决这一差距，我们在一个特别容易受到2型糖尿病健康后果影响的样本中检验了这些变量之间的关系。研究对象为37名诊断为2型糖尿病的暴露于创伤的黑人妇女。高频心率变异性（HF-HRV）、血糖控制（HbA1c）和应激诱发的炎症生物标志物（白细胞介素6；IL-6）作为创伤暴露的遗传风险因素和后果的更大研究的一部分。HbA1c和HF-HRV的相互作用与IL-6反应显著相关，以相对于地面的曲线下面积计算。事后简单斜率分析显示，HbA1c而不是HF-HRV是这种关联的调节因子，因此，只有在HbA1c较低的情况下，较高的HF-HRV才会导致较高的循环IL-6水平（β = 0.60, t = 3.51, p = 0.001）。当控制BMI和年龄时，心血管自主功能和血糖控制与应激源诱发的IL-6反应显著相关。此外，心血管自主功能与炎症之间的关系在不同的HbA1c水平下有所不同。这强调了创伤暴露和2型糖尿病患者可能受益于HbA1c水平分层的可能性，以用于研究分析和治疗决策。血糖和迷走神经控制的相互作用与IL-6反应有关。较高的迷走神经控制只在血糖较低时才会导致更多的炎症。HbA1c水平分层可能有助于研究分析。
Type 2 diabetes mellitus (T2DM) is a major public health problem in the United States. Although cardiovascular autonomic functioning, blood glucose control, and inflammation are known to play a role in T2DM, the interaction between these variables remains largely unexplored, particularly in the context of stress. To address this gap, we examined the relationship between these variables in a sample that is uniquely vulnerable to the health consequences of T2DM. Participants were 37 trauma-exposed Black women with a diagnosis of T2DM. High frequency heart rate variability (HF-HRV), blood glucose control (HbA1c), and a stressor-evoked biomarker of inflammation (interleukin 6; IL-6) were obtained as part of a larger study of the genetic risk factors for and consequences of trauma exposure. The interaction of HbA1c and HF-HRV was significantly associated with IL-6 response calculated as area under the curve with respect to ground. Post-hoc simple slopes analyses revealed HbA1c, rather than HF-HRV, as the moderator in this association such that higher HF-HRV conferred higher circulating levels of IL-6 only in the presence of lower HbA1c, (β = 0.60, t = 3.51, p = .001). Cardiovascular autonomic functioning and blood glucose control were significantly associated with stressor-evoked IL-6 responses when controlling for BMI and age. Moreover, the association between cardiovascular autonomic functioning and inflammation varied at different levels of HbA1c. This highlights the possibility that individuals with trauma exposure and T2DM may benefit from stratification by HbA1c levels for research analysis and treatment decision making. The interaction of blood glucose and vagal control was associated with IL-6 response. Higher vagal control conferred more inflammation only when blood glucose was low. Stratification by HbA1c levels may be useful for research analysis.
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DOI：
10.1038/npp.2010.159
发表时间：
2010-12
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子：
--
作者：
通讯作者：
--
影响因子：
3.7
作者：
Pruessner, JC;Kirschbaum, C;Hellhammer, DH
通讯作者：
Hellhammer, DH
影响因子：
5.1
作者：
Kataoka, M;Ito, C;Kohno, N
通讯作者：
Kohno, N
影响因子：
4.5
作者：
Gluck, Rachel L.;Hartzell, Georgina E.;Dixon, Hayley D.;Michopoulos, Vasiliki;Powers, Abigail;Stevens, Jennifer S.;Fani, Negar;Carter, Sierra;Schwartz, Ann C.;Jovanovic, Tanja;Ressler, Kerry J.;Bradley, Bekh;Gillespie, Charles F.
通讯作者：
Gillespie, Charles F.
影响因子：
2.1
作者：
Parish, Roy C.;Todman, Steven;Jain, Sushil K.
通讯作者：
Jain, Sushil K.