P50 sensory gating in multiplex schizophrenia families from a Pacific island isolate.
P50 sensory gating in multiplex schizophrenia families from a Pacific island isolate.
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来自太平洋岛屿分离株的多重精神分裂症家族中的 P50 感觉门控。
DOI：
10.1176/appi.ajp.159.12.2007
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
Myles-Worsley,Marina
中科院分区：
文献类型：
--
作者：
Myles-Worsley,Marina
目的：对来自密克罗尼西亚帕劳的多重精神分裂症家族进行P50感觉门控（P50 sensory gating）评估，1)检验这种抑制神经生物学性状与非高加索人家族性精神分裂症之间的相关性，2)在这些家族的遗传连锁研究中评估P50性状作为一种内表型的能力。方法采用配对刺激听觉事件相关电位模式检测85例精神分裂症患者（56例服用典型抗精神病药物，29例未服用抗精神病药物）、83例一级亲属（46例父母和37例兄弟姐妹）和29例正常对照者的P50感觉门控。结果与正常人相比，服药和未服药的精神分裂症患者的听觉感觉门控功能受损程度相似，服药剂量对任何P50变量均无显著影响。这种损害延伸到一级亲属，他们的P50比值也明显高于正常受试者。64.7%的精神分裂症患者及其一级亲属存在P50异常，51.8%的精神分裂症患者存在P50异常，而正常人的P50异常仅占10.3%。结论帕劳精神分裂症家族存在sp50感觉门控缺陷。亲属中P50感觉门控异常率与正常受试者的风险比为5.0。损伤与药物作用无关，表明P50范式测量的是一种稳定的神经生物学特征，不受典型抗精神病药物治疗的影响。这些结果表明，在这些多重影响的帕劳家庭中，这种性状可以满足精神分裂症遗传易感的内表型的主要标准。
OBJECTIVEMultiplex schizophrenia families from Palau, Micronesia, were assessed with P50 sensory gating to 1) test for replication of the association between this inhibitory neurobiological trait and familial schizophrenia in non-Caucasian subjects and 2) evaluate the ability of the P50 trait to serve as an endophenotype in a genetic linkage study of these families.METHODA paired-stimulus auditory event- related potential paradigm was used to examine P50 sensory gating in 85 schizophrenia patients (56 medicated with typical antipsychotics and 29 unmedicated), 83 of their first-degree relatives (46 parents and 37 siblings), and 29 normal comparison subjects.RESULTSAuditory sensory gating as measured by the P50 ratio was similarly impaired in medicated and unmedicated schizophrenia patients compared to the normal subjects, and medication dose had no significant effect on any P50 variable. This impairment extended to first-degree relatives, who also showed significantly higher P50 ratios than the normal subjects. Abnormal P50 ratios were found in 64.7% of the schizophrenia patients and 51.8% of their first-degree relatives but only 10.3% of the normal subjects.CONCLUSIONSP50 sensory gating deficits were confirmed in Palauan schizophrenia families. Rates of abnormal P50 sensory gating in relatives versus normal subjects resulted in a risk ratio of 5.0. Impairment was independent of medication effects, indicating that the P50 paradigm measures a stable neurobiological trait unaffected by treatment with typical antipsychotics. These results suggest that this trait can fulfill the major criteria for an endophenotype for genetic liability to schizophrenia in these multiply affected Palauan families.
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影响因子：
--
作者：
C. Siegel;M. Waldo;G. Mizner;L. Adler;R. Freedman
通讯作者：
C. Siegel;M. Waldo;G. Mizner;L. Adler;R. Freedman
DOI：
10.1176/ajp.149.4.488
发表时间：
1992-04
期刊：
The American journal of psychiatry
影响因子：
--
作者：
L. Judd;L. Mcadams;Byron Budnick;D. Braff
通讯作者：
L. Judd;L. Mcadams;Byron Budnick;D. Braff
影响因子：
17.7
作者：
Light, GA;Geyer, MA;Braff, DL
通讯作者：
Braff, DL
诊断准确性和连锁分析：精神分裂症谱系表型有多大用处？
DOI：
10.1176/ajp.152.9.1286
发表时间：
1995
期刊：
The American journal of psychiatry.
影响因子：
--
作者：
Faraone,SV;Kremen,WS;Lyons,MJ;Pepple,JR;Seidman,LJ;Tsuang,MT
通讯作者：
Tsuang,MT
影响因子：
9.8
作者：
Almasy, L;Blangero, J
通讯作者：
Blangero, J