Examining the role of the temporo-parietal network in memory, imagery, and viewpoint transformations.
Examining the role of the temporo-parietal network in memory, imagery, and viewpoint transformations.
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DOI：
10.3389/fnhum.2014.00709
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发表时间：
2014
影响因子：
2.9
通讯作者：
Becker S
中科院分区：
文献类型：
--
作者：
Dhindsa K;Drobinin V;King J;Hall GB;Burgess N;Becker S
传统的内侧颞叶(MTL)研究侧重于其在情景记忆中的作用。然而，MTL的一些潜在功能可以从其在支持与顶叶和前额叶区域协调的空间认知方面的更广泛作用中确定。MTL与持久的同位着丝粒表达的形成密切相关(例如，O‘Keefe，；King等人，；Ekstrom等人，)。根据我们的BBB模型(Byrne等人)，这些表征必须通过涉及脾后区域的转换电路与顶后皮质中以头为中心和以身体为中心的表征相互作用。在长时记忆中，顶区的自我中心感觉表征可以提示对异地中心空间表征的回忆，反过来，在MTL中提取的产物可以在顶层“窗口”内产生心理意象。这样的图像必然是以自我为中心的，并构成视觉空间工作记忆的一部分，在视觉空间工作记忆中，它可以被操纵以计划/想象未来。最近的功能磁共振证据(Lambrey等人，；Zhang等人，)支持BBB模型。为了进一步测试该模型，我们让参与者学习物体在虚拟场景中的位置，并在对转换电路施加不同要求的条件下测试他们的空间记忆。我们分析了大脑活动与判断物体方向的准确性之间的关系：(1)从视觉空间工作记忆(由于任务的顺序和视点没有变化，我们假设是瞬时工作记忆，但长期记忆提取也是可能的)，(2)视点旋转后，或(3)视点旋转和平移后(相对方向判断)。我们在两个需要视点旋转(ROT和JRD，即条件2和3)的任务中都发现了与绩效相关的活动，这些活动发生在BBB模型确定的核心颞叶至内侧顶叶回路中。这些结果与BBB模型的预测一致，并进一步阐明了空间记忆、心理意象和视点转换的神经机制。
The traditional view of the medial temporal lobe (MTL) focuses on its role in episodic memory. However, some of the underlying functions of the MTL can be ascertained from its wider role in supporting spatial cognition in concert with parietal and prefrontal regions. The MTL is strongly implicated in the formation of enduring allocentric representations (e.g., O'Keefe,; King et al.,; Ekstrom et al.,). According to our BBB model (Byrne et al.,), these representations must interact with head-centered and body-centered representations in posterior parietal cortex via a transformation circuit involving retrosplenial areas. Egocentric sensory representations in parietal areas can then cue the recall of allocentric spatial representations in long-term memory and, conversely, the products of retrieval in MTL can generate mental imagery within a parietal “window.” Such imagery is necessarily egocentric and forms part of visuospatial working memory, in which it can be manipulated for the purpose of planning/imagining the future. Recent fMRI evidence (Lambrey et al.,; Zhang et al.,) supports the BBB model. To further test the model, we had participants learn the locations of objects in a virtual scene and tested their spatial memory under conditions that impose varying demands on the transformation circuit. We analyzed how brain activity correlated with accuracy in judging the direction of an object (1) from visuospatial working memory (we assume transient working memory due to the order of tasks and the absence of change in viewpoint, but long-term memory retrieval is also possible), (2) after a rotation of viewpoint, or (3) after a rotation and translation of viewpoint (judgment of relative direction). We found performance-related activity in both tasks requiring viewpoint rotation (ROT and JRD, i.e., conditions 2 and 3) in the core medial temporal to medial parietal circuit identified by the BBB model. These results are consistent with the predictions of the BBB model, and shed further light on the neural mechanisms underlying spatial memory, mental imagery and viewpoint transformations.
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影响因子：
64.8
作者：
Epstein, R;Kanwisher, N
通讯作者：
Kanwisher, N
影响因子：
64.8
作者：
Ekstrom, AD;Kahana, MJ;Fried, I
通讯作者：
Fried, I
影响因子：
5.7
作者：
Genovese, CR;Lazar, NA;Nichols, T
通讯作者：
Nichols, T
影响因子：
2.9
作者：
Postle, Bradley R.;D'Esposito, Mark
通讯作者：
D'Esposito, Mark
影响因子：
3.7
作者：
Lambrey, Simon;Doeller, Christian;Burgess, Neil
通讯作者：
Burgess, Neil