A physiological increase of insulin in the olfactory bulb decreases detection of a learned aversive odor and abolishes food odor-induced sniffing behavior in rats.
A physiological increase of insulin in the olfactory bulb decreases detection of a learned aversive odor and abolishes food odor-induced sniffing behavior in rats.
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DOI：
10.1371/journal.pone.0051227
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Julliard AK
中科院分区：
文献类型：
--
作者：
Aimé P;Hegoburu C;Jaillard T;Degletagne C;Garcia S;Messaoudi B;Thevenet M;Lorsignol A;Duchamp C;Mouly AM;Julliard AK
胰岛素参与多种调节机制，包括体重和食物摄入量，并在肥胖和糖尿病等代谢紊乱中发挥关键作用。越来越多的证据表明，胰岛素也参与了嗅觉功能的调节。嗅球(OB)含有大脑中最高水平的胰岛素和胰岛素受体(IR)。然而，胰岛素在气味检测和嗅觉行为中的作用仍有待阐明。用条件性嗅觉厌恶(COA)对乙酸异戊酯气味的行为范式，我们证明侧脑室(Icv)注射14 mU胰岛素可显著降低对禁食大鼠的嗅觉检测，使其达到饱足动物的水平。此外，虽然禁食动物在食物气味检测中表现出呼吸频率的增加，但在接受14亩胰岛素脑室注射的禁食动物以及饱足的动物中，这种影响是不存在的。同时，我们发现，与禁食大鼠相比，饱食大鼠的空腹血糖和血浆胰岛素水平都有所升高，并且14 mU胰岛素侧脑室注射使禁食大鼠的空腹胰岛素水平上升到饱食大鼠的水平。我们进一步量化了胰岛素受体(IRS)的分布，发现IRS优先在主要OB的尾部和外侧部分表达，其中最高标记的是二尖瓣细胞，即主要的OB投射神经元。综上所述，这些数据表明，胰岛素作用于OB网络来调节嗅觉处理，并证明嗅觉功能受参与能量稳态调节和摄食行为的信号控制。
Insulin is involved in multiple regulatory mechanisms, including body weight and food intake, and plays a critical role in metabolic disorders such as obesity and diabetes. An increasing body of evidence indicates that insulin is also involved in the modulation of olfactory function. The olfactory bulb (OB) contains the highest level of insulin and insulin receptors (IRs) in the brain. However, a role for insulin in odor detection and sniffing behavior remains to be elucidated. Using a behavioral paradigm based on conditioned olfactory aversion (COA) to isoamyl-acetate odor, we demonstrated that an intracerebroventricular (ICV) injection of 14 mU insulin acutely decreased olfactory detection of fasted rats to the level observed in satiated animals. In addition, whereas fasted animals demonstrated an increase in respiratory frequency upon food odor detection, this effect was absent in fasted animals receiving a 14 mU insulin ICV injection as well as in satiated animals. In parallel, we showed that the OB and plasma insulin levels were increased in satiated rats compared to fasted rats, and that a 14 mU insulin ICV injection elevated the OB insulin level of fasted rats to that of satiated rats. We further quantified insulin receptors (IRs) distribution and showed that IRs are preferentially expressed in the caudal and lateral parts of the main OB, with the highest labeling found in the mitral cells, the main OB projection neurons. Together, these data suggest that insulin acts on the OB network to modulate olfactory processing and demonstrate that olfactory function is under the control of signals involved in energy homeostasis regulation and feeding behaviors.
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影响因子：
16.2
作者：
Abraham, NM;Spors, H;Schaefer, AT
通讯作者：
Schaefer, AT
影响因子：
3.8
作者：
BRIEF, DJ;DAVIS, JD
通讯作者：
DAVIS, JD
影响因子：
3.5
作者：
Buonviso, N;Amat, C;Litaudon, P
通讯作者：
Litaudon, P
影响因子：
2.5
作者：
Courtiol, Emmanuelle;Hegoburu, Chloe;Buonviso, Nathalie
通讯作者：
Buonviso, Nathalie
DOI：
10.1046/j.1440-1681.1999.03073.x
发表时间：
1999-07-01
影响因子：
2.9
作者：
Delattre, E;Cipolla-Neto, J;Boschero, AC
通讯作者：
Boschero, AC