Associations of in utero exposure to perfluorinated alkyl acids with human semen quality and reproductive hormones in adult men.
Associations of in utero exposure to perfluorinated alkyl acids with human semen quality and reproductive hormones in adult men.
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DOI：
10.1289/ehp.1205118
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发表时间：
2013-04
影响因子：
10.4
通讯作者：
Toft G
中科院分区：
文献类型：
--
作者：
Vested A;Ramlau-Hansen CH;Olsen SF;Bonde JP;Kristensen SL;Halldorsson TI;Becher G;Haug LS;Ernst EH;Toft G
背景资料：全氟烷基酸（PFAAs）是一种具有独特防水、防污和防油特性的持久性化学品，被怀疑具有内分泌干扰活性。全氟辛酸（PFOA）和全氟辛烷磺酸（PFOS）的化合物在全球范围内都存在于人类体内;因为它们很容易穿过胎盘屏障，子宫内的暴露可能是一个令人担忧的原因。目的：我们调查子宫内暴露于PFOA和PFOS是否会影响精液质量、睾丸体积和生殖激素水平。研究方法：我们从1988 - 1989年在丹麦奥胡斯建立的妊娠队列中招募了169名男性后代（19 - 21岁），相当于合格儿子的37.6%。每个人都提供了精液样本和血液样本。分析精液样本的精子浓度、精子总数、活力和形态，并使用血液样本测量生殖激素。作为子宫内暴露的替代指标，测量了怀孕第30周母体血液样本中的PFOA和PFOS。结果如下：多变量线性回归分析表明，子宫内暴露于PFOA与较低的调整后精子浓度（ptrend = 0.01）和精子总数（ptrend = 0.001）以及较高的调整后促黄体激素（ptrend = 0.03）和促卵泡激素（ptrend = 0.01）水平相关。在调整之前或之后，全氟辛烷磺酸似乎与任何评估结果无关。结论：结果表明，在子宫内暴露于PFOA可能会影响成年男性精液质量和生殖激素水平。
Background: Perfluorinated alkyl acids (PFAAs), persistent chemicals with unique water-, dirt-, and oil-repellent properties, are suspected of having endocrine-disrupting activity. The PFAA compounds perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS) are found globally in humans; because they readily cross the placental barrier, in utero exposure may be a cause for concern. Objectives: We investigated whether in utero exposure to PFOA and PFOS affects semen quality, testicular volume, and reproductive hormone levels. Methods: We recruited 169 male offspring (19–21 years of age) from a pregnancy cohort established in Aarhus, Denmark, in 1988–1989, corresponding to 37.6% of the eligible sons. Each man provided a semen sample and a blood sample. Semen samples were analyzed for sperm concentration, total sperm count, motility, and morphology, and blood samples were used to measure reproductive hormones. As a proxy for in utero exposure, PFOA and PFOS were measured in maternal blood samples from pregnancy week 30. Results: Multivariable linear regression analysis suggested that in utero exposure to PFOA was associated with lower adjusted sperm concentration (ptrend = 0.01) and total sperm count (ptrend = 0.001) and with higher adjusted levels of luteinizing hormone (ptrend = 0.03) and follicle-stimulating hormone (ptrend = 0.01). PFOS did not appear to be associated with any of the outcomes assessed, before or after adjustment. Conclusions: The results suggest that in utero exposure to PFOA may affect adult human male semen quality and reproductive hormone levels.
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影响因子：
5.4
作者：
Jensen, Morten Sondergaard;Rebordosa, Cristina;Olsen, Jorn
通讯作者：
Olsen, Jorn
影响因子：
10.4
作者：
Mocarelli P;Gerthoux PM;Needham LL;Patterson DG Jr;Limonta G;Falbo R;Signorini S;Bertona M;Crespi C;Sarto C;Scott PK;Turner WE;Brambilla P
通讯作者：
Brambilla P
DOI：
10.1016/j.reprotox.2011.05.024
发表时间：
2012-07
期刊：
Reproductive toxicology (Elmsford, N.Y.)
影响因子：
--
作者：
Raymer JH;Michael LC;Studabaker WB;Olsen GW;Sloan CS;Wilcosky T;Walmer DK
通讯作者：
Walmer DK
影响因子：
6
作者：
Palmer, Julie R.;Herbst, Arthur L.;Hoover, Robert N.
通讯作者：
Hoover, Robert N.
影响因子：
11.8
作者：
Haug, Line S.;Huber, Sandra;Thomsen, Cathrine
通讯作者：
Thomsen, Cathrine