Concentrations of perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) and their associations with human semen quality measurements.
Concentrations of perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) and their associations with human semen quality measurements.
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DOI：
10.1016/j.reprotox.2011.05.024
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发表时间：
2012-07
期刊：
影响因子：
--
通讯作者：
Walmer DK
中科院分区：
文献类型：
--
作者：
Raymer JH;Michael LC;Studabaker WB;Olsen GW;Sloan CS;Wilcosky T;Walmer DK
共对256名男性进行了研究，以评估全氟辛烷酸（PFOA）和全氟辛烷磺酸（PFOS）的血清浓度是否影响精液质量或生殖激素。采集血液和精液，分析全氟化学物质、生殖激素和甲状腺激素。采用标准临床方法评估精液质量。以精液剖面测量作为结果，精液和血浆中的全氟辛烷磺酸和全氟辛烷磺酸作为解释变量，进行线性和逻辑建模。调整年龄、戒烟和吸烟，没有迹象表明PFOA或PFOS与体积、精子浓度、运动百分比、游泳运动和浓度以及定向运动（运动和模态进展的函数）显著相关。促卵泡激素与全氟辛烷磺酸或全氟辛烷磺酸均无关联。黄体生成素与血浆PFOA、PFOS呈正相关，与精液PFOS无显著正相关。重要的方法学问题包括缺乏处理昼夜节律所需的多种激素测量。
A total of 256 men were studied to evaluate whether serum concentrations of perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) impacted semen quality or reproductive hormones. Blood and semen were collected and analyzed for perfluorochemicals and reproductive and thyroid hormones. Semen quality was assessed using standard clinical methods. Linear and logistic modeling was performed with semen profile measurements as outcomes and PFOS and PFOA in semen and plasma as explanatory variables. Adjusting for age, abstinence, and tobacco use, there was no indication that PFOA or PFOS was significantly associated with volume, sperm concentration, percent motility, swim-up motility and concentration, and directional motility (a function of motility and modal progression.) Follicle stimulating hormone was not associated with either PFOA or PFOS. Luteinizing hormone was positively correlated with plasma PFOA and PFOS, but not semen PFOS. Important methodological concerns included the lack of multiple hormonal measurements necessary to address circadian rhythms.
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