Susceptibility to Ticks and Lyme Disease Spirochetes Is Not Affected in Mice Coinfected with Nematodes
Susceptibility to Ticks and Lyme Disease Spirochetes Is Not Affected in Mice Coinfected with Nematodes
复制标题
混合感染线虫的小鼠对蜱和莱姆病螺旋体的易感性不受影响
DOI：
10.1128/iai.01309-15
复制
发表时间：
2016
影响因子：
3.1
通讯作者：
S. Hartmann.
中科院分区：
文献类型：
--
作者：
S. Rausch;D. Richter;J. Krücken;A.A. Kühl;J. Demeler;J. Blümke;F.R. Matuschka;G. von Samson-Himmelstjerna;S. Hartmann.
小型啮齿动物是蜱传病原体的储存宿主，如导致莱姆病的螺旋体。与其他大型寄生虫的自然合并感染是否会改变蜱虫喂养的成功，抗蜱免疫力，以及宿主对蜱传病原体的储库能力仍有待确定。在德国柏林的一项野生小鼠寄生虫学调查中，约40%的受蓖麻硬蜱感染的动物同时携带一种螺旋体属线虫。因此，我们的目的是分析线虫/蜱共感染的免疫学影响，以及其对蜱传病原体阿氏疏螺旋体的影响。实验共感染多脑Heligmosomoides polygyrus和幼虫/若虫I.基于加塔-3和白细胞介素-13的表达水平，与感染单一病原体的小鼠相比，蓖麻蜱产生了显著更强的系统性2型T辅助细胞（Th 2）应答。然而，在反复的幼虫感染，抗蜱Th 2反应和观察到的部分免疫蜱喂养并发线虫感染的影响。重要的是，在共感染小鼠中，强的全身性Th 2免疫应答并不影响对蜱传B的易感性。afzelii。观察到局部和全身Th 1对B的反应性降低的趋势。在共感染的小鼠中，阿氏杆菌没有导致更高的螺旋体负荷，也没有促进细菌传播或诱导免疫病理学的迹象。因此，这项研究表明，在线虫/蜱共感染的家鼠强全身性Th 2反应不影响蜱喂养的成功和莱姆病的病原体的控制。
Small rodents serve as reservoir hosts for tick-borne pathogens, such as the spirochetes causing Lyme disease. Whether natural coinfections with other macroparasites alter the success of tick feeding, antitick immunity, and the host's reservoir competence for tick-borne pathogens remains to be determined. In a parasitological survey of wild mice in Berlin, Germany, approximately 40% of Ixodes ricinus-infested animals simultaneously harbored a nematode of the genus Heligmosomoides. We therefore aimed to analyze the immunological impact of the nematode/tick coinfection as well as its effect on the tick-borne pathogen Borrelia afzelii. Hosts experimentally coinfected with Heligmosomoides polygyrus and larval/nymphal I. ricinus ticks developed substantially stronger systemic type 2 T helper cell (Th2) responses, on the basis of the levels of GATA-3 and interleukin-13 expression, than mice infected with a single pathogen. During repeated larval infestations, however, anti-tick Th2 reactivity and an observed partial immunity to tick feeding were unaffected by concurrent nematode infections. Importantly, the strong systemic Th2 immune response in coinfected mice did not affect susceptibility to tick-borne B. afzelii. An observed trend for decreased local and systemic Th1 reactivity against B. afzelii in coinfected mice did not result in a higher spirochete burden, nor did it facilitate bacterial dissemination or induce signs of immunopathology. Hence, this study indicates that strong systemic Th2 responses in nematode/tick-coinfected house mice do not affect the success of tick feeding and the control of the causative agent of Lyme disease.
登录
查看更多内容
蓖麻硬蜱的抗原谱：发育阶段、摄食时间和不同宿主物种反应的影响
DOI：
--
发表时间：
2001
期刊：
Parasite immunology (Print)
影响因子：
--
作者：
C. Lawrie;P. Nuttall
通讯作者：
P. Nuttall
从柏林/德国勃兰登堡的狗收集的壁虱中的病原体。
影响因子：
3.2
作者：
Schreiber C;Krücken J;Beck S;Maaz D;Pachnicke S;Krieger K;Gross M;Kohn B;von Samson-Himmelstjerna G
通讯作者：
von Samson-Himmelstjerna G
影响因子：
3.1
作者：
Rausch, Sebastian;Huehn, Jochen;Hartmann, Susanne
通讯作者：
Hartmann, Susanne
莱姆病疏螺旋体螺旋体的外表面蛋白刺激 T 细胞分泌干扰素-γ (IFN-γ)：诊断和致病意义
影响因子：
4.6
作者：
P. Forsberg;J. Ernerudh;C. Ekerfelt;M. Roberg;M. Vrethem;S. Bergström
通讯作者：
S. Bergström
影响因子：
3.1
作者：
Richter, D;Klug, B;Matuschka, FR
通讯作者：
Matuschka, FR