A preliminary study of the neural correlates of the intensities of self-reported gambling urges and emotions in men with pathological gambling.
A preliminary study of the neural correlates of the intensities of self-reported gambling urges and emotions in men with pathological gambling.
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DOI：
10.1007/s10899-011-9259-8
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发表时间：
2012-09
影响因子：
2.4
通讯作者：
Potenza, Marc N.
中科院分区：
文献类型：
--
作者：
Balodis, Iris M.;Lacadie, Cheryl M.;Potenza, Marc N.
虽然自我报告的赌博冲动强度在病理性赌博(PG)的治疗中具有临床实用价值，但先前的研究尚未调查它们的神经相关性。10名患有PG的男性和11名对照(CON)男性观看了赌博、快乐或悲伤内容的录像，并进行了功能磁共振成像(FMRI)。参与者对他们的情绪和动机的强度进行了评级，并报告了他们的反应质量。与CON组相比，PG组报告了对悲伤和快乐场景的类似反应，但在观看赌博场景时，情绪反应和赌博冲动更强。在报告的情绪/动机反应开始期间，自我报告的反应和大脑激活之间的相关性通常最强，在所有情况下，PG组比CON受试者更强。在这一时期，与有意识地意识到情绪/动机反应相对应，PG组赌博冲动的主观评分与内侧前额叶皮质的激活呈负相关，与颞中回和颞极的激活呈正相关。在PG组中，悲伤评分与内侧眶前叶皮质、颞中回和脾后皮质的激活呈正相关，而在快乐视频中自我报告的快乐程度与颞极的激活呈显著负相关。在PG受试者中发现的大脑区域与外显、自我参照加工和情景记忆有关。研究结果表明，在PG和CON被试中，当观看相应内容的材料时，情绪和动机的主观测量之间存在不同的相关模式，这表明在PG中，神经的变化与潜在的情感加工的经验方面相关。
Although self-reported gambling urge intensities have clinical utility in the treatment of pathological gambling (PG), prior studies have not investigated their neural correlates. Functional magnetic resonance imaging (fMRI) was conducted while 10 men with PG and 11 control comparison (CON) men viewed videotaped scenarios of gambling, happy or sad content. Participants rated the intensity of their emotions and motivations and reported the qualities of their responses. Relative to the CON group, the PG group reported similar responses to sad and happy scenarios, but stronger emotional responses and gambling urges when viewing the gambling scenarios. Correlations between self-reported responses and brain activations were typically strongest during the period of reported onset of emotional/motivational response and more robust in PG than in CON subjects for all conditions. During this epoch, corresponding with conscious awareness of an emotional/motivational response, subjective ratings of gambling urges in the PG group were negatively correlated with medial prefrontal cortex activation and positively correlated with middle temporal gyrus and temporal pole activations. Sadness ratings in the PG group correlated positively with activation of the medial orbitofrontal cortex, middle temporal gyrus, and retrosplenial cortex, while self-reported happiness during the happy videos demonstrated largely inverse correlations with activations in the temporal poles. Brain areas identified in the PG subjects have been implicated in explicit, self-referential processing and episodic memory. The findings demonstrate different patterns of correlations between subjective measures of emotions and motivations in PG and CON subjects when viewing material of corresponding content, suggesting in PG alterations in the neural correlates underlying experiential aspects of affective processing.
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影响因子：
--
作者：
Blumberg, HP;Leung, HC;Peterson, BS
通讯作者：
Peterson, BS
影响因子：
2.4
作者：
Bechara, Antoine
通讯作者：
Bechara, Antoine
影响因子：
7.6
作者：
de Ruiter, Michiel B.;Veltman, Dick J.;van den Brink, Wim
通讯作者：
van den Brink, Wim
影响因子：
10.6
作者：
Brewer, Judson A.;Worhunsky, Patrick D.;Carroll, Kathleen M.;Rounsaville, Bruce J.;Potenza, Marc N.
通讯作者：
Potenza, Marc N.
影响因子：
3.4
作者：
Goudriaan AE;de Ruiter MB;van den Brink W;Oosterlaan J;Veltman DJ
通讯作者：
Veltman DJ