Maternal determinants of infant immunity: Implications for effective immunization and maternal-child health.
Maternal determinants of infant immunity: Implications for effective immunization and maternal-child health.
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DOI：
10.1016/j.vaccine.2020.01.056
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发表时间：
2020-06-09
期刊：
影响因子：
5.5
通讯作者：
Marchant A
中科院分区：
文献类型：
--
作者：
Pasetti MF;Ackerman ME;Hoen AG;Alter G;Tsang JS;Marchant A
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Infectious diseases remain a major contributor of infant morbidity and mortality globally, especially in low-and middle-income countries. Newborns, in particular, bear a disproportionate burden, estimated at 7 million cases and 700,000 deaths per year (1). Routine immunization, which prevents many infectious diseases during childhood, has had limited impact preventing illness during the first months of life, partly due to newborns’ reduced ability to rapidly mount an effective response to these vaccines (2). On the other hand, strengthening of maternal health and immune fitness holds tremendous potential to reduce vulnerability to infection and promote well-being of both mothers and infants. Infants born to healthy mothers are more resilient to infection and likely to grow and develop to their full potential (ideal trajectory of steady health, Figure 1), whereas those born to unhealthy mothers are more likely to fall into a cycle of increased susceptibility to disease and death (the vulnerable trajectory, Figure 1). Repeated bouts of illness reduce quality of life, and the resulting cumulative disadvantages can perpetuate for generations. Although the path of vulnerability involves multiple economic and social aspects, initiatives aimed at improving maternal health through disease prevention and treatment can increase infant survival, reduce vulnerability, and promote childhood health and lifelong wellness.To this end, vaccination during pregnancy seeks to protect mothers and infants from infectious threats by boosting maternal cellular and humoral immunity. The offspring benefit from the placental sieve of systemic antibodies and from mucosal antibodies, cells, and immunomodulatory and regulatory molecules, which constitute the “immune system” in
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