Beneficial Effects of Metformin on the Central Nervous System, with a Focus on Epilepsy and Lafora Disease.
Beneficial Effects of Metformin on the Central Nervous System, with a Focus on Epilepsy and Lafora Disease.
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DOI：
10.3390/ijms22105351
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发表时间：
2021-05-19
影响因子：
5.6
通讯作者：
Sánchez MP
中科院分区：
文献类型：
--
作者：
Sanz P;Serratosa JM;Sánchez MP
Metformin is a drug in the family of biguanide compounds that is widely used in the treatment of type 2 diabetes (T2D). Interestingly, the therapeutic potential of metformin expands its prescribed use as an anti-diabetic drug. In this sense, it has been described that metformin administration has beneficial effects on different neurological conditions. In this work, we review the beneficial effects of this drug as a neuroprotective agent in different neurological diseases, with a special focus on epileptic disorders and Lafora disease, a particular type of progressive myoclonus epilepsy. In addition, we review the different proposed mechanisms of action of metformin to understand its function at the neurological level.
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影响因子：
4.7
作者：
Andreasson KI;Bachstetter AD;Colonna M;Ginhoux F;Holmes C;Lamb B;Landreth G;Lee DC;Low D;Lynch MA;Monsonego A;O'Banion MK;Pekny M;Puschmann T;Russek-Blum N;Sandusky LA;Selenica ML;Takata K;Teeling J;Town T;Van Eldik LJ
通讯作者：
Van Eldik LJ
影响因子：
3.5
作者：
Aguado C;Sarkar S;Korolchuk VI;Criado O;Vernia S;Boya P;Sanz P;de Córdoba SR;Knecht E;Rubinsztein DC
通讯作者：
Rubinsztein DC
影响因子：
5.1
作者：
Berthier A;Payá M;García-Cabrero AM;Ballester MI;Heredia M;Serratosa JM;Sánchez MP;Sanz P
通讯作者：
Sanz P
影响因子：
3.3
作者：
Antel, Jack P.;Lin, Yun Hsuan;Healy, Luke M.
通讯作者：
Healy, Luke M.
影响因子：
20.1
作者：
Cameron AR;Morrison VL;Levin D;Mohan M;Forteath C;Beall C;McNeilly AD;Balfour DJ;Savinko T;Wong AK;Viollet B;Sakamoto K;Fagerholm SC;Foretz M;Lang CC;Rena G
通讯作者：
Rena G