Single-Prolonged Stress: A Review of Two Decades of Progress in a Rodent Model of Post-traumatic Stress Disorder.
Single-Prolonged Stress: A Review of Two Decades of Progress in a Rodent Model of Post-traumatic Stress Disorder.
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DOI：
10.3389/fpsyt.2018.00196
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发表时间：
2018
影响因子：
4.7
通讯作者：
Perrine SA
中科院分区：
文献类型：
--
作者：
Lisieski MJ;Eagle AL;Conti AC;Liberzon I;Perrine SA
创伤后应激障碍（PTSD）是一种常见的，昂贵的，往往使人衰弱的精神疾病。然而，这种疾病背后的生物学机制在很大程度上仍然是未知的或知之甚少。相当多的证据表明，创伤后应激障碍是由高度保守的大脑系统功能障碍引起的，这些系统涉及压力、焦虑、恐惧和奖励。创伤应激暴露的临床前模型在定义PTSD的神经生物学机制方面至关重要，这将最终有助于开发PTSD的新治疗方法。单一长期应激（SPS）是一种临床前模型，其表现出行为、分子和生理变化，这些变化概括了在PTSD中观察到的许多相同变化，说明了其有效性，并使其作为研究创伤后适应和创伤前风险和保护因素的模型。在这篇文章中，我们回顾了SPS模型的研究现状，目的是（1）描述SPS模型作为研究创伤后适应的工具的实用性，（2）将SPS模型的研究结果与PTSD患者的研究结果联系起来，（3）指出研究差距和解决这些问题的策略，以提高我们对PTSD病理生理学的理解。
Post-traumatic stress disorder (PTSD) is a common, costly, and often debilitating psychiatric condition. However, the biological mechanisms underlying this disease are still largely unknown or poorly understood. Considerable evidence indicates that PTSD results from dysfunction in highly-conserved brain systems involved in stress, anxiety, fear, and reward. Pre-clinical models of traumatic stress exposure are critical in defining the neurobiological mechanisms of PTSD, which will ultimately aid in the development of new treatments for PTSD. Single prolonged stress (SPS) is a pre-clinical model that displays behavioral, molecular, and physiological alterations that recapitulate many of the same alterations observed in PTSD, illustrating its validity and giving it utility as a model for investigating post-traumatic adaptations and pre-trauma risk and protective factors. In this manuscript, we review the present state of research using the SPS model, with the goals of (1) describing the utility of the SPS model as a tool for investigating post-trauma adaptations, (2) relating findings using the SPS model to findings in patients with PTSD, and (3) indicating research gaps and strategies to address them in order to improve our understanding of the pathophysiology of PTSD.
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