Fibroblast biology. Development and differentiation of synovial fibroblasts in arthritis.

Fibroblast biology. Development and differentiation of synovial fibroblasts in arthritis.
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DOI:
10.1186/ar110
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发表时间:
2000
期刊:
Arthritis research
影响因子:
--
通讯作者:
Edwards JC
Edwards JC
中科院分区:
其他
文献类型:
--
作者:
Edwards JC

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滑膜成纤维细胞有两种表型-内膜和内膜下。特异性内膜表型包括尿苷二磷酸葡萄糖脱氢酶(UDPGD)、血管细胞粘附分子-1(VCAM-1)和补体衰变加速因子(CRIF)的表达。这些基因产物有助于与组织运动和白细胞运输相关的专门功能。
Synovial fibroblasts occur as two phenotypes - intimal and subintimal. The specialised intimal phenotype includes expression of uridine diphosphoglucose dehydrogenase (UDPGD), vascular cell adhesion molecule-1 (VCAM-1) and complement decay-accelerating factor (DAF). These gene products contribute to specialised functions relating to tissue movement and leucocyte traffic.
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