Small non-coding RNA SraG regulates the operon YPK_1206-1205 in Yersinia pseudotuberculosis.
Small non-coding RNA SraG regulates the operon YPK_1206-1205 in Yersinia pseudotuberculosis.
复制标题
小非编码 RNA SraG 调节假结核耶尔森氏菌中的操纵子 YPK_1206-1205。
DOI:
10.1111/j.1574-6968.2012.02548.x
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发表时间:
2012-06
影响因子:
2.1
通讯作者:
张勇
中科院分区:
文献类型:
--
作者:
张勇
Small non-coding RNAs (sRNAs) are important post-transcriptional regulators in prokaryotes and have been demonstrated to participate in most of the cellular processes. SraG is an sRNA found in several enterobacterial species, but its targets have not been characterized. Here, we compared the protein expression patterns between the wild-type and an sraG-depleted mutant of Yersinia pseudotuberculosis by proteomic analysis. Sixteen proteins were up- or downregulated, and the negative regulatory role of SraG associated with the YPK_1206-1205 operon was confirmed. A region in the coding sequence of YPK_1206 was further demonstrated to be required for this negative regulation.
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