Association of the FAM46A gene VNTRs and BAG6 rs3117582 SNP with non small cell lung cancer (NSCLC) in Croatian and Norwegian populations.
Association of the FAM46A gene VNTRs and BAG6 rs3117582 SNP with non small cell lung cancer (NSCLC) in Croatian and Norwegian populations.
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DOI：
10.1371/journal.pone.0122651
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Dembic Z
中科院分区：
文献类型：
--
作者：
Etokebe GE;Zienolddiny S;Kupanovac Z;Enersen M;Balen S;Flego V;Bulat-Kardum L;Radojčić-Badovinac A;Skaug V;Bakke P;Haugen A;Dembic Z
我们分析了克罗地亚和挪威受试者中具有序列相似性46的家族成员A（FAM 46 A）基因中可变数目串联重复（VNTR）多态性和BCL 2相关的Athanogene 6（BAG 6）中单核苷酸多态性（rs3117582）与非小细胞肺癌之间的关联。共分析了503例（262名克罗地亚人和241名挪威人）非小细胞肺癌患者和897例对照（568名克罗地亚人和329名挪威人）。我们发现，在克罗地亚和合并的克罗地亚和挪威受试者中，与健康对照相比，患者中FAM 46 A基因的等位基因B（三个VNTR重复）的频率显著增加。与克罗地亚和挪威受试者中的健康对照相比，患者中FAM 46 A基因的cd（4个和5个VNTR重复）和cc（4个VNTR重复纯合子）的基因型频率分别显著降低。Logistic回归分析显示，在校正年龄、性别和吸烟状况后，FAM 46 A基因型cc是挪威受试者非小细胞肺癌风险的独立预测因子。这是首次提示FAM 46 A基因VNTR多态性与非小细胞肺癌相关的研究。我们还发现BAG 6 rs3117582 SNP与挪威受试者和挪威-挪威联合受试者中的非小细胞肺癌相关，证实了早期发现BAG 6 rs3117582 SNP与欧洲人肺癌相关。Logistic回归分析显示，在校正年龄和性别后，BAG 6基因型和等位基因是挪威人和挪威-挪威联合受试者非小细胞肺癌风险的独立预测因素。
We analyzed for associations between a variable number of tandem repeat (VNTR) polymorphism in the Family with sequence similarity 46, member A (FAM46A) gene and a single nucleotide polymorphism (rs3117582) in the BCL2-Associated Athanogene 6 (BAG6) with non small cell lung cancer in Croatian and Norwegian subjects. A total of 503 (262 Croatian and 241Norwegian) non small cell lung cancer patients and 897 controls (568 Croatian and 329 Norwegian) were analyzed. We found that the frequency of allele b (three VNTR repeats) of FAM46A gene was significantly increased in the patients compared to the healthy controls in the Croatian and the combined Croatian and Norwegian subjects. Genotype frequencies of cd (four and five VNTR repeats) and cc (four VNTR repeats homozygote) of the FAM46A gene were significantly decreased in the patients compared to the healthy controls in the Croatian and Norwegian subjects, respectively. Logistic regression analyses revealed FAM46A genotype cc to be an independent predictive factor for non small cell lung cancer risk in the Norwegian subjects after adjustment for age, gender and smoking status. This is the first study to suggest an association between the FAM46A gene VNTR polymorphisms and non small cell lung cancer. We found also that BAG6 rs3117582 SNP was associated with non small cell lung cancer in the Norwegian subjects and the combined Croatian-Norwegian subjects corroborating the earlier finding that BAG6 rs3117582 SNP was associated with lung cancer in Europeans. Logistic regression analyses revealed that genotypes and alleles of BAG6 were independent predictive factor for non small cell lung cancer risk in the Norwegian and combined Croatian-Norwegian subjects, after adjustment for age and gender.
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影响因子：
5
作者：
Cui, Jing;Wang, Wei;Yao, Chan
通讯作者：
Yao, Chan
影响因子：
8.4
作者：
Cote, Michele L.;Liu, Mei;Bonassi, Stefano;Neri, Monica;Schwartz, Ann G.;Christiani, David C.;Spitz, Margaret R.;Muscat, Joshua E.;Rennert, Gad;Aben, Katja K.;Andrew, Angeline S.;Bencko, Vladimir;Bickeboeller, Heike;Boffetta, Paolo;Brennan, Paul;Brenner, Hermann;Duell, Eric J.;Fabianova, Eleonora;Field, John K.;Foretova, Lenka;Friis, Soren;Harris, Curtis C.;Holcatova, Ivana;Hong, Yun-Chul;Isla, Dolores;Janout, Vladimir;Kiemeney, Lambertus A.;Kiyohara, Chikako;Lan, Qing;Lazarus, Philip;Lissowska, Jolanta;Le Marchand, Loic;Mates, Dana;Matsuo, Keitaro;Mayordomo, Jose I.;McLaughlin, John R.;Morgenstern, Hal;Mueeller, Heiko;Orlow, Irene;Park, Bernard J.;Pinchev, Mila;Raji, Olaide Y.;Rennert, Hedy S.;Rudnai, Peter;Seow, Adeline;Stucker, Isabelle;Szeszenia-Dabrowska, Neonila;Teare, M. Dawn;Tjonnelan, Anne;Ugolini, Donatella;van der Heijden, Henricus F. M.;Wichmann, Erich;Wiencke, John K.;Woll, Penella J.;Yang, Ping;Zaridze, David;Zhang, Zuo-Feng;Etzel, Carol J.;Hung, Rayjean J.
通讯作者：
Hung, Rayjean J.
影响因子：
14.9
作者：
Kuchta K;Knizewski L;Wyrwicz LS;Rychlewski L;Ginalski K
通讯作者：
Ginalski K
DOI：
10.1016/s0006-291x(02)00228-0
发表时间：
2002-04-26
影响因子：
3.1
作者：
Lagali, PS;Kakuk, LE;Ayyagari, R
通讯作者：
Ayyagari, R
影响因子：
5.3
作者：
Hart, Kent;Landvik, Nina E.;Zienolddiny, Shanbeh
通讯作者：
Zienolddiny, Shanbeh