The neuropsychological profiles and semantic-critical regions of right semantic dementia.
The neuropsychological profiles and semantic-critical regions of right semantic dementia.
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DOI：
10.1016/j.nicl.2018.05.035
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Guo Q
中科院分区：
文献类型：
--
作者：
Chen K;Ding J;Lin B;Huang L;Tang L;Bi Y;Han Z;Lv Y;Guo Q
以往的研究表明，前颞叶（ATL）是左侧或混合语义性痴呆（SD）的语义中枢，而右侧SD的语义中枢尚未得到研究。17例右侧SD患者，18例左侧SD患者和20例正常对照（NC）进行神经心理学评估和磁共振成像扫描。我们分别研究了左侧和右侧SD样本的全脑脑萎缩程度与语义缺陷严重程度之间的关系。我们发现右侧SD患者的语义缺陷与双侧梭状回和左侧颞极相关，而左侧梭状回与左侧SD患者的语义表现相关。此外，所有的发现都不能用总灰质体积（GMV）或患者的一般认知退化来解释。这些结果为当前的语义理论提供了新的证据，即语义加工的重要区域包括前颞叶和后颞叶。左侧SD在命名、阅读和Stroop测验中的损害更严重。右侧SD在符号数字模式任务上表现出更多的缺陷。左侧梭状回与左侧SD的语义表现相关。右侧SD的语义中枢为双侧梭状回和左侧颞极。
Previous literature has revealed that the anterior temporal lobe (ATL) is the semantic hub of left-sided or mixed semantic dementia (SD), whilst the semantic hub of right-sided SD has not been examined. Seventeen patients with right-sided SD, 18 patients with left-sided SD and 20 normal controls (NC) underwent neuropsychological assessments and magnetic resonance imaging scans. We investigated the relationship between the degree of cerebral atrophy in the whole brain and the severity of semantic deficits in left and right-sided SD samples, respectively. We found the semantic deficits of right-sided SD patients were related to bilateral fusiform gyri and left temporal pole, whilst the left fusiform gyrus correlated with the semantic performance of left-sided SD patients. Moreover, all the findings couldn't be accounted for by total gray matter volume (GMV) or general cognitive degradation of patients. These results provide novel evidence for the current semantic theory, that the important regions for semantic processing include both anterior and posterior temporal lobes. Left SD presented more impairment on the naming, reading and Stroop tests. Right SD exhibited more deficits on the symbol digit modalities task. Left fusiform gyrus correlated with the semantic performance of left SD. The semantic hubs of right SD were bilateral fusiform gyri and left temporal pole.
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DOI：
10.1016/j.cortex.2016.05.014
发表时间：
2016-09
期刊：
Cortex; a journal devoted to the study of the nervous system and behavior
影响因子：
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作者：
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