Endoplasmic reticulum-mitochondria contacts: function of the junction.

Endoplasmic reticulum-mitochondria contacts: function of the junction.
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DOI:
10.1038/nrm3440
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发表时间:
2012-10
期刊:
Nature reviews. Molecular cell biology
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其他
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最具特征的细胞器接触位点是内质网和线粒体之间的接触位点。人们对er -线粒体接触位点是如何组织的以及哪些因子聚集在这个界面上有了越来越多的了解,其中一些可能提供了系绳功能。er -线粒体连接在协调这两个细胞器功能中的作用也越来越清楚,它已被证明参与调节脂质合成,Ca2+信号传导和线粒体生物发生和细胞内运输的控制。
The most well-characterized organelle contact sites are those between the endoplasmic reticulum (ER) and mitochondria. Increased understanding is being gained of how ER–mitochondria contact sites are organized and which factors converge at this interface, some of which may provide a tethering function. The role of the ER–mitochondria junction in coordinating the functions of these two organelles is also becoming clearer, and it has been shown to be involved in the regulation of lipid synthesis, Ca2+ signalling and the control of mitochondrial biogenesis and intracellular trafficking.
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