Early Brain Loss in Circuits Affected by Alzheimer's Disease is Predicted by Fornix Microstructure but may be Independent of Gray Matter.
Early Brain Loss in Circuits Affected by Alzheimer's Disease is Predicted by Fornix Microstructure but may be Independent of Gray Matter.
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DOI：
10.3389/fnagi.2014.00106
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发表时间：
2014
影响因子：
4.8
通讯作者：
DeCarli C
中科院分区：
文献类型：
--
作者：
Fletcher E;Carmichael O;Pasternak O;Maier-Hein KH;DeCarli C
在一组社区招募的认知正常的老年受试者中，我们发现基线穹窿白色物质（WM）微结构与感兴趣区域（称为穹窿显著ROI，fSROI）的早期体积纵向组织变化显著相关，该区域与已知选择性易受阿尔茨海默氏痴呆病理影响的回路重叠。其他WM和灰质区域与纵向组织变化的相关性要弱得多或不存在。fSROI中的组织损失反过来是认知下降的存活模型中的重要因素，基线穹窿微结构也是如此。这些发现表明，穹窿WM恶化和fSROI组织损失可能是后边缘回路和默认模式网络退化的早期开始。我们还发现，在存活模型中，内嗅皮层和海马的灰质基线体积预测认知能力下降。但是，由于GM区域也没有显著预测脑组织的损失，我们的研究结果可能意味着一种观点，即早期的前驱退化在对记忆至关重要的边缘回路的白色和灰质区域中表现为两个准独立的过程。
In a cohort of community-recruited elderly subjects with normal cognition at initial evaluation, we found that baseline fornix white matter (WM) microstructure was significantly correlated with early volumetric longitudinal tissue change across a region of interest (called fornix significant ROI, fSROI), which overlaps circuits known to be selectively vulnerable to Alzheimer’s dementia pathology. Other WM and gray matter regions had much weaker or non-existent associations with longitudinal tissue change. Tissue loss in fSROI was in turn a significant factor in a survival model of cognitive decline, as was baseline fornix microstructure. These findings suggest that WM deterioration in the fornix and tissue loss in fSROI may be the early beginnings of posterior limbic circuit and default mode network degeneration. We also found that gray matter baseline volumes in the entorhinal cortex and hippocampus predicted cognitive decline in survival models. But since GM regions did not also significantly predict brain-tissue loss, our results may imply a view in which early, prodromal deterioration appears as two quasi independent processes in white and gray matter regions of the limbic circuit crucial to memory.
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DOI：
10.1073/pnas.0308627101
发表时间：
2004-03-30
影响因子：
11.1
作者：
Greicius, MD;Srivastava, G;Menon, V
通讯作者：
Menon, V
影响因子：
4.8
作者：
Lee DY;Fletcher E;Carmichael OT;Singh B;Mungas D;Reed B;Martinez O;Buonocore MH;Persianinova M;Decarli C
通讯作者：
Decarli C
影响因子：
4.2
作者：
Carmichael, Owen;Mungas, Dan;Beckett, Laurel;Harvey, Danielle;Farias, Sarah Tomaszewski;Reed, Bruce;Olichney, John;Miller, Joshua;DeCarli, Charles
通讯作者：
DeCarli, Charles
影响因子：
5.7
作者：
Hua X;Leow AD;Parikshak N;Lee S;Chiang MC;Toga AW;Jack CR Jr;Weiner MW;Thompson PM;Alzheimer's Disease Neuroimaging Initiative
通讯作者：
Alzheimer's Disease Neuroimaging Initiative
影响因子：
11.2
作者：
Nestor, PJ;Fryer, TD;Hodges, JR
通讯作者：
Hodges, JR