Sub-Regional Hippocampal Injury is Associated with Fornix Degeneration in Alzheimer's Disease.
Sub-Regional Hippocampal Injury is Associated with Fornix Degeneration in Alzheimer's Disease.
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DOI：
10.3389/fnagi.2012.00001
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发表时间：
2012
影响因子：
4.8
通讯作者：
Decarli C
中科院分区：
文献类型：
--
作者：
Lee DY;Fletcher E;Carmichael OT;Singh B;Mungas D;Reed B;Martinez O;Buonocore MH;Persianinova M;Decarli C
我们通过穹窿微结构完整性分析和海马子区萎缩的测量，研究了阿尔茨海默病（AD）中与神经元病理学相关的轴突变性的体内证据。基于已知的解剖学地形，我们假设，海马下托和CA1区的局部厚度与穹窿的完整性相关，反映了AD相关的海马神经元损伤和相关轴突纤维变性之间的关联。为了验证这一假设，多模态成像，结合扩散张量成像（DTI）的局部海马半径的措施，被应用于44个临床诊断为AD的人，44个临床诊断为轻度认知障碍（MCI）的人，和96个认知正常的人。穹窿微结构退化，减少DTI为基础的各向异性分数（FA），是突出的MCI和AD，并与海马体积减少。此外，穹窿FA减少与前CA1和前内侧下托厚度减少相关。最后，虽然较小的穹窿FA和较小的海马体积与较少的情景记忆相关，但在包括海马和穹窿预测因子的模型中，只有海马测量是情景记忆的显著预测因子。穹窿完整性和海马神经元死亡之间的区域特异性关联可能为AD中退行性白色物质损伤提供体内证据：轴突病理与神经元损伤密切相关。
We examined in vivo evidence of axonal degeneration in association with neuronal pathology in Alzheimer’s disease (AD) through analysis of fornix microstructural integrity and measures of hippocampal subfield atrophy. Based on known anatomical topography, we hypothesized that the local thickness of subiculum and CA1 hippocampus fields would be associated with fornix integrity, reflecting an association between AD-related injury to hippocampal neurons and degeneration of associated axon fibers. To test this hypothesis, multi-modal imaging, combining measures of local hippocampal radii with diffusion tensor imaging (DTI), was applied to 44 individuals clinically diagnosed with AD, 44 individuals clinically diagnosed with mild cognitive impairment (MCI), and 96 cognitively normal individuals. Fornix microstructural degradation, as measured by reduced DTI-based fractional anisotropy (FA), was prominent in both MCI and AD, and was associated with reduced hippocampal volumes. Further, reduced fornix FA was associated with reduced anterior CA1 and antero-medial subiculum thickness. Finally, while both lesser fornix FA and lesser hippocampal volume were associated with lesser episodic memory, only the hippocampal measures were significant predictors of episodic memory in models including both hippocampal and fornix predictors. The region-specific association between fornix integrity and hippocampal neuronal death may provide in vivo evidence for degenerative white matter injury in AD: axonal pathology that is closely linked to neuronal injury.
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影响因子：
9.9
作者：
Csernansky, JG;Wang, L;Miller, MI
通讯作者：
Miller, MI
影响因子：
4.2
作者：
Bartzokis G
通讯作者：
Bartzokis G
影响因子：
4.2
作者：
Carmichael, Owen;Mungas, Dan;Beckett, Laurel;Harvey, Danielle;Farias, Sarah Tomaszewski;Reed, Bruce;Olichney, John;Miller, Joshua;DeCarli, Charles
通讯作者：
DeCarli, Charles
影响因子：
4.2
作者：
Bartzokis, G;Sultzer, D;Cummings, JL
通讯作者：
Cummings, JL
影响因子：
4.2
作者：
Forsberg, Anton;Engler, Henry;Nordberg, Agneta
通讯作者：
Nordberg, Agneta