Association of prediabetes and diabetes with stroke symptoms: the REasons for Geographic and Racial Differences in Stroke (REGARDS) study.
Association of prediabetes and diabetes with stroke symptoms: the REasons for Geographic and Racial Differences in Stroke (REGARDS) study.
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DOI：
10.2337/dc11-2140
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发表时间：
2012-09
期刊：
影响因子：
16.2
通讯作者：
Safford MM
中科院分区：
文献类型：
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作者：
Carson AP;Muntner P;Kissela BM;Kleindorfer DO;Howard VJ;Meschia JF;Williams LS;Prineas RJ;Howard G;Safford MM
在没有医生诊断为卒中的个体中，卒中症状与未来卒中风险增加相关。很少有研究评估糖尿病或前驱糖尿病患者，但没有医生诊断的中风，是否有中风症状的患病率增加。本研究纳入了25，696名来自卒中地理和种族差异原因（REGARDS）研究的年龄≥45岁的受试者，这些受试者在基线时（2003-2007年）未报告卒中或短暂性脑缺血发作病史。血糖测量、药物使用和自我报告的医生诊断被用来将参与者分为糖尿病、前驱糖尿病或正常糖尿病组。使用经验证的问卷评估六种卒中症状的存在。与糖尿病前期（15.6%）或正常脑卒中（14.9%）相比，糖尿病患者（22.7%）中任何卒中症状的患病率均较高。在多变量模型中，与正常对照组相比，糖尿病与任何卒中症状（患病率比值比[POR] 1.28 [95%CI 1.18-1.39]）和两种或多种卒中症状（1.26 [1.12-1.43]）相关。在对个体卒中症状的分析中，经多变量调整后，糖尿病与麻木（1.15 [1.03-1.29]）、视力丧失（1.52 [1.31-1.76]）、半视力丧失（1.54 [1.30-1.84]）和理解他人能力丧失（1.34 [1.12-1.61]）相关。前驱糖尿病和中风症状之间没有关联。在这项基于人群的研究中，几乎四分之一的糖尿病患者报告了中风症状，这表明糖尿病患者的中风症状筛查可能是必要的。
Stroke symptoms among individuals reporting no physician diagnosis of stroke are associated with an increased risk of future stroke. Few studies have assessed whether individuals with diabetes or prediabetes, but no physician diagnosis of stroke, have an increased prevalence of stroke symptoms. This study included 25,696 individuals aged ≥45 years from the REasons for Geographic And Racial Differences in Stroke (REGARDS) study who reported no history of stroke or transient ischemic attack at baseline (2003–2007). Glucose measurements, medication use, and self-reported physician diagnosis were used to categorize participants into diabetes, prediabetes, or normal glycemia groups. The presence of six stroke symptoms was assessed using a validated questionnaire. The prevalence of any stroke symptom was higher among participants with diabetes (22.7%) compared with those with prediabetes (15.6%) or normal glycemia (14.9%). In multivariable models, diabetes was associated with any stroke symptom (prevalence odds ratio [POR] 1.28 [95% CI 1.18–1.39]) and two or more stroke symptoms (1.26 [1.12–1.43]) compared with normal glycemia. In analyses of individual stroke symptoms, diabetes was associated with numbness (1.15 [1.03–1.29]), vision loss (1.52 [1.31–1.76]), half-vision loss (1.54 [1.30–1.84]), and lost ability to understand people (1.34 [1.12–1.61]) after multivariable adjustment. No association was present between prediabetes and stroke symptoms. In this population-based study, almost one in four individuals with diabetes reported stroke symptoms, which suggests that screening for stroke symptoms in diabetes may be warranted.
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影响因子：
16.2
作者：
Mann DM;Carson AP;Shimbo D;Fonseca V;Fox CS;Muntner P
通讯作者：
Muntner P
影响因子：
16.2
作者：
Cowie CC;Rust KF;Ford ES;Eberhardt MS;Byrd-Holt DD;Li C;Williams DE;Gregg EW;Bainbridge KE;Saydah SH;Geiss LS
通讯作者：
Geiss LS
影响因子：
37.8
作者：
Alberti, K. G. M. M.;Eckel, Robert H.;Smith, Sidney C., Jr.
通讯作者：
Smith, Sidney C., Jr.
影响因子：
8.3
作者：
Howard, G;Wagenknecht, LE;Toole, JF
通讯作者：
Toole, JF
影响因子：
--
作者：
Najarian, RM;Sullivan, LM;Wolf, PA
通讯作者：
Wolf, PA