A household serosurvey to estimate the magnitude of a dengue outbreak in Mombasa, Kenya, 2013.
A household serosurvey to estimate the magnitude of a dengue outbreak in Mombasa, Kenya, 2013.
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DOI：
10.1371/journal.pntd.0003733
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发表时间：
2015-04
影响因子：
3.8
通讯作者：
Tomashek KM
中科院分区：
文献类型：
--
作者：
Ellis EM;Neatherlin JC;Delorey M;Ochieng M;Mohamed AH;Mogeni DO;Hunsperger E;Patta S;Gikunju S;Waiboic L;Fields B;Ofula V;Konongoi SL;Torres-Velasquez B;Marano N;Sang R;Margolis HS;Montgomery JM;Tomashek KM
登革热似乎是非洲的地方病，据报道发生了一些疫情。2013年2月，在肯尼亚蒙巴萨发现了几名登革热样疾病患者，但疟疾血涂片呈阴性。登革热经实验室确认，并进行了调查，以估计当地传播的程度，包括血清学调查，以确定登革热病毒（DENV）感染事件。健康的家庭成员提供了血清，并询问了暴露情况和病史。RT-PCR用于鉴定当前DENV感染，IgM抗DENV ELISA用于鉴定近期感染。在来自701个家庭的1,500名参与者中，210人（13%）有当前或最近感染DENV的证据。在感染者中，93人（44%）在过去一个月内报告发烧。大多数（68.73%）发热感染的参与者被临床医生看到，32名据报道接受诊断的参与者中，除一人外，其他人都被临床诊断为患有疟疾。夜间开窗（OR = 2.3; CI：1.1-4.8）、每日不使用驱蚊剂（OR = 1.6; CI：1.0-2.8）和近期到肯尼亚境外旅行（OR = 2.5; CI：1.1-5.4）与DENV感染风险增加相关。这项调查提供了一个强有力的措施，事件登革病毒感染的情况下，往往无法识别和误诊。登革热似乎是非洲的地方病，据报道发生了一些疫情。2013年2月，在肯尼亚蒙巴萨发现了几名登革热样疾病患者，但疟疾血涂片呈阴性。登革热经实验室确认，并进行了调查，以估计当地传播的程度，包括血清学调查，以确定登革热病毒（DENV）感染事件。健康的家庭成员提供了血清，并询问了暴露情况和病史。RT-PCR用于鉴定当前DENV感染，IgM抗DENV ELISA用于鉴定近期感染。在1，500名参与者中，13%有当前或最近感染DENV的证据。在感染者中，44%的人在过去一个月内报告发烧。大多数（73%）发热感染的参与者都是由临床医生看到的，32名据报道接受诊断的参与者中，除一人外，其他人都被临床诊断为疟疾。夜间开窗、不使用日常驱蚊剂以及最近在肯尼亚以外地区旅行与DENV感染风险增加有关。这项调查提供了一个强有力的措施，事件登革病毒感染的情况下，往往无法识别和误诊。
Dengue appears to be endemic in Africa with a number of reported outbreaks. In February 2013, several individuals with dengue-like illnesses and negative malaria blood smears were identified in Mombasa, Kenya. Dengue was laboratory confirmed and an investigation was conducted to estimate the magnitude of local transmission including a serologic survey to determine incident dengue virus (DENV) infections. Consenting household members provided serum and were questioned regarding exposures and medical history. RT-PCR was used to identify current DENV infections and IgM anti-DENV ELISA to identify recent infections. Of 1,500 participants from 701 households, 210 (13%) had evidence of current or recent DENV infection. Among those infected, 93 (44%) reported fever in the past month. Most (68, 73%) febrile infected participants were seen by a clinician and all but one of 32 participants who reportedly received a diagnosis were clinically diagnosed as having malaria. Having open windows at night (OR = 2.3; CI: 1.1–4.8), not using daily mosquito repellent (OR = 1.6; CI: 1.0–2.8), and recent travel outside of Kenya (OR = 2.5; CI: 1.1–5.4) were associated with increased risk of DENV infection. This survey provided a robust measure of incident DENV infections in a setting where cases were often unrecognized and misdiagnosed. Dengue appears to be endemic in Africa with a number of reported outbreaks. In February 2013, several individuals with dengue-like illnesses and negative malaria blood smears were identified in Mombasa, Kenya. Dengue was laboratory confirmed and an investigation was conducted to estimate the magnitude of local transmission including a serologic survey to determine incident dengue virus (DENV) infections. Consenting household members provided serum and were questioned regarding exposures and medical history. RT-PCR was used to identify current DENV infections and IgM anti-DENV ELISA to identify recent infections. Of 1,500 participants, 13% had evidence of current or recent DENV infection. Among those infected, 44% reported fever in the past month. Most (73%) febrile infected participants were seen by a clinician, and all but one of the 32 participants who reportedly received a diagnosis were clinically diagnosed as having malaria. Having open windows at night, not using daily mosquito repellent, and recent travel outside of Kenya were associated with increased risk of DENV infection. This survey provided a robust measure of incident DENV infections in a setting where cases were often unrecognized and misdiagnosed.
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DOI：
10.1136/bmj.e4389
发表时间：
2012-07-24
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Leslie T;Mikhail A;Mayan I;Anwar M;Bakhtash S;Nader M;Chandler C;Whitty CJ;Rowland M
通讯作者：
Rowland M
影响因子：
3.8
作者：
Sabchareon, Arunee;Sirivichayakul, Chukiat;Letson, G. William
通讯作者：
Letson, G. William
影响因子：
4.8
作者：
Mease, Luke E.;Coldren, Rodney L.;Adungo, Nicholas
通讯作者：
Adungo, Nicholas
DOI：
10.1016/j.cimid.2004.03.013
发表时间：
2004-09-01
影响因子：
2
作者：
Gubler, DJ
通讯作者：
Gubler, DJ
影响因子：
2.1
作者：
Reiter, Paul
通讯作者：
Reiter, Paul