Background fish feminization effects in European remote sites.
Background fish feminization effects in European remote sites.
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DOI：
10.1038/srep11292
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发表时间：
2015-06-10
影响因子：
4.6
通讯作者：
Piña B
中科院分区：
文献类型：
--
作者：
Jarque S;Quirós L;Grimalt JO;Gallego E;Catalan J;Lackner R;Piña B
人类活动已经将微量的化学稳定的内分泌干扰污染物扩散到整个生物圈。这些化合物产生了雌激素活性的背景水平，需要进行评估。鱼类是雌性化效应的适当哨兵，因为雄性标本比人类对外源性雌激素化合物更敏感。高山湖泊是大陆地区最遥远的环境，只接受大气沉积的半挥发性化合物。我们分析了来自欧洲这些山区湖泊的雄鱼中雌激素调节基因的表达水平。涉及雌激素受体和辐射带基因表达的早期女性化揭示了广泛的弥漫性雌激素影响。这种影响与鱼类中某些有机氯化合物的浓度相关，并且与这些对流层污染物在最偏远的行星地区持续存在的情况一致。这些结果应引起普遍关注，因为内分泌干扰效应在人群中日益增加。
Human activity has spread trace amounts of chemically stable endocrine-disrupting pollutants throughout the biosphere. These compounds have generated a background level of estrogenic activity that needs to be assessed. Fish are adequate sentinels for feminization effects as male specimens are more sensitive than humans to exogenous estrogenic compounds. High mountain lakes, the most distant environments of continental areas, only receive semi-volatile compounds from atmospheric deposition. We analyzed the expression levels of estrogen-regulated genes in male fish from these mountain lakes in Europe. Incipient feminization involving expression of estrogen receptor and zona radiata genes revealed a widespread diffuse estrogenic impact. This effect was correlated with the concentrations of some organochlorine compounds in fish and was consistent with the persistent occurrence of these tropospheric pollutants in the most remote planet regions. These results should be of general concern given the increasing endocrine disruption effects in human populations.
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影响因子：
4.3
作者：
García-Reyero, N;Raldúa, D;Piña, B
通讯作者：
Piña, B
影响因子：
8.9
作者：
Garcia-Reyero, Natalia;Grimalt, Joan O.;Pina, Benjamin
通讯作者：
Pina, Benjamin
影响因子：
10.4
作者：
Harris CA;Hamilton PB;Runnalls TJ;Vinciotti V;Henshaw A;Hodgson D;Coe TS;Jobling S;Tyler CR;Sumpter JP
通讯作者：
Sumpter JP
影响因子：
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作者：
Denslow, Nancy D.;Garcia-Reyero, Natalia;Barber, David S.
通讯作者：
Barber, David S.
影响因子：
8.9
作者：
Jarque, Sergio;Gallego, Eva;Pina, Benjamin
通讯作者：
Pina, Benjamin