Alterations of microbiota structure in the larynx relevant to laryngeal carcinoma.
Alterations of microbiota structure in the larynx relevant to laryngeal carcinoma.
复制标题
与喉癌相关的喉部微生物群结构的改变
DOI：
10.1038/s41598-017-05576-7
复制
发表时间：
2017-07-14
影响因子：
4.6
通讯作者：
Zhou L
中科院分区：
文献类型：
--
作者：
Gong H;Shi Y;Xiao X;Cao P;Wu C;Tao L;Hou D;Wang Y;Zhou L
生活在喉粘膜中的微生物群落建立了稳定的微环境，并有可能影响人类喉咙的健康。然而，微生物区系结构与喉癌之间的关系仍不确定。在这里，我们通过高通量焦磷酸测序比较喉癌患者和声带息肉对照组的喉部微生物区系结构来探索这个问题。总体而言，链球菌属、梭杆菌属和普雷沃特拉属是喉部的主要细菌种群。收集31例喉癌患者的肿瘤组织和癌旁正常组织(NAT)，比较喉癌患者和32例正常对照组织中的细菌群落。肿瘤组织和NAT中喉部群落的比较显示，癌症患者的α多样性高于对照组，并且三组样本中7个细菌属的相对丰度不同。此外，喉癌患者的10个细菌属的相对丰度与对照组有显著差异。这些发现表明，喉癌患者的喉部微生物区系特征发生了改变，这表明微生物区系结构的紊乱可能与喉癌有关。
The microbial communities that inhabit the laryngeal mucosa build stable microenvironments and have the potential to influence the health of the human throat. However, the associations between the microbiota structure and laryngeal carcinoma remain uncertain. Here, we explored this question by comparing the laryngeal microbiota structure in laryngeal cancer patients with that in control subjects with vocal cord polyps through high-throughput pyrosequencing. Overall, the generaStreptococcus,Fusobacterium, andPrevotellawere prevalent bacterial populations in the laryngeal niche. Tumor tissue samples and normal tissues adjacent to the tumor sites (NATs) were collected from 31 laryngeal cancer patients, and the bacterial communities in laryngeal cancer patients were compared with control samples from 32 subjects. A comparison of the laryngeal communities in the tumor tissues and the NATs showed higher α-diversity in cancer patients than in control subjects, and the relative abundances of seven bacterial genera differed among the three groups of samples. Furthermore, the relative abundances of ten bacterial genera in laryngeal cancer patients differed substantially from those in control subjects. These findings indicate that the laryngeal microbiota profiles are altered in laryngeal cancer patients, suggesting that a disturbance of the microbiota structure might be relevant to laryngeal cancer.
登录
查看更多内容
影响因子：
6.4
作者：
Blanchette-Cain K;Hinojosa CA;Akula Suresh Babu R;Lizcano A;Gonzalez-Juarbe N;Munoz-Almagro C;Sanchez CJ;Bergman MA;Orihuela CJ
通讯作者：
Orihuela CJ
影响因子：
7
作者：
Castellarin, Mauro;Warren, Rene L.;Holt, Robert A.
通讯作者：
Holt, Robert A.
影响因子：
14.9
作者：
Cole JR;Wang Q;Cardenas E;Fish J;Chai B;Farris RJ;Kulam-Syed-Mohideen AS;McGarrell DM;Marsh T;Garrity GM;Tiedje JM
通讯作者：
Tiedje JM
DOI：
10.1126/science.1224820
发表时间：
2012-10-05
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Arthur JC;Perez-Chanona E;Mühlbauer M;Tomkovich S;Uronis JM;Fan TJ;Campbell BJ;Abujamel T;Dogan B;Rogers AB;Rhodes JM;Stintzi A;Simpson KW;Hansen JJ;Keku TO;Fodor AA;Jobin C
通讯作者：
Jobin C
影响因子：
2.8
作者：
Groeger, Sabine;Domann, Eugen;Meyle, Joerg
通讯作者：
Meyle, Joerg