Dietary cholesterol degrades rabbit long term memory for discrimination learning but facilitates acquisition of discrimination reversal.
Dietary cholesterol degrades rabbit long term memory for discrimination learning but facilitates acquisition of discrimination reversal.
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DOI：
10.1016/j.nlm.2013.09.010
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发表时间：
2013-11
影响因子：
2.7
通讯作者：
Burhans, Lauren B.
中科院分区：
文献类型：
--
作者：
Schreurs, Bernard G.;Smith-Bell, Carrie A.;Wang, Desheng;Burhans, Lauren B.
关键词：
我们之前已经表明，在学习前摄入膳食胆固醇可以改善习得，而在学习后摄入胆固醇会降低长期记忆。为了在单一范式中检查这些不同的发现，我们给几组兔子喂食 2% 胆固醇或正常食物，在饮用水中添加或不添加 0.12 ppm 铜，然后进行瞬膜反应的双音辨别学习，其中 8 kHz 音调（条件刺激，CS+）之后是吹气，而 1 kHz 音调（CS−）则不是。节食八周后，我们评估了兔子在测试和再训练过程中的条件反应。然后，我们反转双音辨别并评估对 1 kHz 音 CS+ 和 8 kHz CS− 的响应。在测试过程中，给予不含铜的胆固醇的兔子对 CS+ 的反应水平低于其他组的兔子，这表明它们也没有保留这种歧视。然而，在短暂的歧视再培训过程中，他们对 CS+ 的反应水平恢复到其他组的水平，表明原始歧视的记忆恢复了。在辨别逆转结束时，这些相同的兔子表现出优异的辨别能力，表现为对 CS− 的反应水平较低，但与 CS+ 的水平相似，表明它们能够通过抑制 CS− 反应更好地获得两种音调之间的新关系。这些结果补充了我们之前的数据，表明胆固醇饮食引起的旧记忆退化和新记忆的促进都可以在歧视逆转范式中得到证明。鉴于歧视逆转是一种依赖于海马体的学习形式，这些数据支持胆固醇在改变海马体功能中的作用，正如我们之前通过体外脑切片记录所显示的那样。
We have shown previously that feeding dietary cholesterol before learning can improve acquisition whereas feeding cholesterol after learning can degrade long term memory. To examine these different findings within a single paradigm, we fed groups of rabbits 2% cholesterol or normal chow with or without 0.12 ppm copper added to the drinking water following two-tone discrimination learning of the nictitating membrane response in which a 8-kHz tone (conditioned stimulus, CS+) was followed by air puff and a 1-kHz tone (CS−) was not. After eight weeks on the diet, we assessed the rabbits’ conditioned responding during testing and retraining. We then reversed the two-tone discrimination and assessed responding to the 1-kHz tone CS+ and the 8-kHz CS−. During testing, rabbits given cholesterol without copper had lower levels of responding to CS+ than rabbits in the other groups suggesting they did not retain the discrimination as well. However, during a brief discrimination retraining session, their response levels to the CS+ returned to the level of the other groups, demonstrating a return of the memory of the original discrimination. At the end of discrimination reversal, these same rabbits exhibited superior discrimination indexed by lower response levels to CS− but similar levels to CS+, suggesting they were better able to acquire the new relationship between the two tones by inhibiting CS− responses. These results add to our previous data by showing cholesterol diet-induced degradation of an old memory and facilitation of a new memory can both be demonstrated within a discrimination reversal paradigm. Given discrimination reversal is a hippocampally-dependent form of learning, the data support the role of cholesterol in modifying hippocampal function as we have shown previously with in vitro brain slice recordings.
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DOI：
10.1073/pnas.93.24.13534
发表时间：
1996-11-26
影响因子：
11.1
作者：
Gabrieli, JDE
通讯作者：
Gabrieli, JDE
影响因子：
3.5
作者：
Fester, Lars;Zhou, Lepu;Rune, Gabriele M.
通讯作者：
Rune, Gabriele M.
影响因子：
--
作者：
Aizenstein, Howard Jay;Nebes, Robert D.;Saxton, Judith A.;Price, Julie C.;Mathis, Chester A.;Tsopelas, Nicholas D.;Ziolko, Scott K.;James, Jeffrey A.;Snitz, Beth E.;Houck, Patricia R.;Bi, Wenzhu;Cohen, Ann D.;Lopresti, Brian J.;DeKosky, Steven T.;Halligan, Edythe M.;Klunk, William E.
通讯作者：
Klunk, William E.
影响因子：
4
作者：
Deci, Stephen;Lemieux, Susan K.;Schreurs, Bernard G.
通讯作者：
Schreurs, Bernard G.
影响因子：
3.4
作者：
Bekisz, Marek;Garkun, Yury;Kossut, Malgorzata
通讯作者：
Kossut, Malgorzata