Neural Mechanisms of Facial Emotion Recognition in Autism: Distinct Roles for Anterior Cingulate and dlPFC.
Neural Mechanisms of Facial Emotion Recognition in Autism: Distinct Roles for Anterior Cingulate and dlPFC.
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DOI：
10.1080/15374416.2022.2051528
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发表时间：
2022-05
影响因子：
4.2
通讯作者：
White, Susan W.
中科院分区：
文献类型：
--
作者：
Richey, John A.;Gracanin, Denis;LaConte, Stephen;Lisinski, Jonathan;Kim, Inyoung;Coffman, Marika;Antezana, Ligia;Carlton, Corinne N.;Garcia, Katelyn M.;White, Susan W.
本研究旨在测量和内部验证患有ASD的青少年和年轻人的面部情绪识别（FER）的神经标志物，以提供有针对性的干预。我们利用功能磁共振成像来测量ASD患者（N=21）和匹配对照组（CON; N=20）在判断六种不同面部情绪（快乐，悲伤，愤怒，惊讶，恐惧，厌恶）的身份之前两秒的大脑活动模式。功能磁共振成像数据的预测建模（支持向量分类; SVC）确定了大脑区域的机械作用，预测正确和不正确的面部情绪识别以及这些决策的错误来源。在对照组和ASD组中，双侧前额叶、前扣带（ACC）和右背外侧前额叶皮层（dlPFC）的BOLD信号激活先于准确的FER。利用SVC的预测建模证实了ACC在预测控制中的正确决策而不是ASD中的实用性，并进一步表明右dlPFC内的区域是ASD中的1型错误信号的来源（即反映即将发生的正确判断的神经标记，随后是不正确的行为反应），大约在fMRI期间的情感判断之前两秒。ACC只在控制参与者中预测正确的决策。右下丘脑前额叶皮层是一个假阳性信号的来源之前，一个错误的性质，面部情绪在青少年和年轻的成年人与ASD，可能与以前的工作表明，下丘脑前额叶皮层可能发挥作用，注意和调节情绪的经验。
The present study sought to measure and internally validate neural markers of facial emotion recognition (FER) in adolescents and young adults with ASD to inform targeted intervention. We utilized fMRI to measure patterns of brain activity among individuals with ASD (N=21) and matched controls (CON; N=20) two seconds prior to judgements about the identity of six distinct facial emotions (happy, sad, angry, surprised, fearful, disgust). Predictive modeling of fMRI data (support vector classification; SVC) identified mechanistic roles for brain regions that forecasted correct and incorrect identification of facial emotion as well as sources of errors over these decisions. BOLD signal activation in bilateral insula, anterior cingulate (ACC) and right dorsolateral prefrontal cortex (dlPFC) preceded accurate FER in both controls and ASD. Predictive modeling utilizing SVC confirmed the utility of ACC in forecasting correct decisions in controls but not ASD, and further indicated that a region within the right dlPFC was the source of a type 1 error signal in ASD (i.e. neural marker reflecting an impending correct judgment followed by an incorrect behavioral response) approximately two seconds prior to emotion judgements during fMRI. ACC forecasted correct decisions only among control participants. Right dlPFC was the source of a false positive signal immediately prior to an error about the nature of a facial emotion in adolescents and young adults with ASD, potentially consistent with prior work indicating that dlPFC may play a role in attention to and regulation of emotional experience.
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影响因子：
3.5
作者：
Abraham A;Pedregosa F;Eickenberg M;Gervais P;Mueller A;Kossaifi J;Gramfort A;Thirion B;Varoquaux G
通讯作者：
Varoquaux G
DOI：
10.1080/13803395.2016.1230595
发表时间：
2017-05-01
影响因子：
2.2
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影响因子：
5.7
作者：
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影响因子：
2.7
作者：
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通讯作者：
Barbas H