Multi-parameter MRI to investigate vasculature modulation and photo-thermal ablation combination therapy against cancer.
Multi-parameter MRI to investigate vasculature modulation and photo-thermal ablation combination therapy against cancer.
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多参数 MRI 研究脉管系统调节和光热消融联合治疗癌症。
DOI：
10.1016/j.nano.2018.07.008
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发表时间：
2018-10
期刊：
影响因子：
--
通讯作者：
Xie J
中科院分区：
文献类型：
--
作者：
Li Y;Ye J;Zhou S;Bai R;Fu G;Zhang W;Zhang IX;Liu G;Zhang F;Xie J
Nanotransducer-mediated photothermal therapy (PTT) has emerged as an attractive therapy modality against cancer, but its efficacy is often limited by the amount of nanoparticles delivered to tumors. Previous studies showed a vasculature modulation treatment, which dilates or prunes tumor blood vessels, may enhance tumor uptake of nanoparticles. However, exploiting these approaches for improved PTT has seldom been studied. In this study, we investigated the impact of mild hyperthermia or anti-angiogenesis therapy on PTT. Briefly, we gave tumor-bearing balb/c mice low doses of sunitinib or submerged tumors in a 42 °C water bath. Next, we injected PEGylated reduced graphene oxide (RGO-PEG) and irradiated the tumors to induce PTT. We then followed up the treatment with multi-parameter MRI. Contrary to expectation, both vessel modulation strategies led to diminished PTT efficacy. Our results show that vessel modulation does not warrant improved PTT, and should be carefully gauged when used in combination with PTT.
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影响因子：
5.4
作者：
Barnes SL;Whisenant JG;Loveless ME;Yankeelov TE
通讯作者：
Yankeelov TE
影响因子：
3.9
作者：
Day, Emily S.;Thompson, Patrick A.;Zhang, Linna;Lewinski, Nastassja A.;Ahmed, Nabil;Drezek, Rebekah A.;Blaney, Susan M.;West, Jennifer L.
通讯作者：
West, Jennifer L.
影响因子：
2.6
作者：
Jeon, T. Y.;Kim, C. K.;Lee, J. H.
通讯作者：
Lee, J. H.
扩散加权磁共振成像用于光热疗法的治疗反应监测和早期治疗预测
影响因子：
9.5
作者：
Fu G;Zhu L;Yang K;Zhuang R;Xie J;Zhang F
通讯作者：
Zhang F
影响因子：
19.7
作者：
Li, Sonia P.;Taylor, N. Jane;Padhani, Anwar R.
通讯作者：
Padhani, Anwar R.