Diffusion-Weighted Magnetic Resonance Imaging for Therapy Response Monitoring and Early Treatment Prediction of Photothermal Therapy.
Diffusion-Weighted Magnetic Resonance Imaging for Therapy Response Monitoring and Early Treatment Prediction of Photothermal Therapy.
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扩散加权磁共振成像用于光热疗法的治疗反应监测和早期治疗预测
DOI：
10.1021/acsami.5b11936
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发表时间：
2016-03-02
影响因子：
9.5
通讯作者：
Zhang F
中科院分区：
文献类型：
--
作者：
Fu G;Zhu L;Yang K;Zhuang R;Xie J;Zhang F
光热疗法(PTT)作为一种较新的癌症治疗方法，已引起世界各国的广泛关注。以往对PTT的研究主要集中在其治疗效率和选择性上。然而，PTT的早期预后，作为评估治疗和治疗分层的关键，却很少被研究。在本研究中，我们研究了弥散加权磁共振成像(DW-MRI)作为PTT治疗监测和早期预后的工具。为此，我们将聚乙二醇化氧化石墨烯(GO-PEG)或氧化铁沉积的氧化石墨烯(GO-IONP-PEG)注射到4T1肿瘤模型中，并以不同的药物-光间隔照射肿瘤以诱导PTT。对于注射GO-IONP-PEG的动物，我们还包括治疗臂，在治疗臂中，向肿瘤施加外部磁场，以改善纳米颗粒换能器的输送。于PTT后不同时间点行DW-MRI检查，分析比较肿瘤表观扩散系数(ADC)。我们的研究表明，光热剂、磁引导和药物光间隔都可以影响PTT的治疗效果。令人印象深刻的是，PTT后早期时间点(小于48h)的ADC值变化被发现与数天或数周后明显的肿瘤生长抑制密切相关。这些变化对生存期超过4周的情况最为敏感，在这种情况下，48h的ADC值增加了80%以上。这些研究首次证明，DW-MRI可以作为PTT的准确预测工具，表明它在未来PTT的评估和临床翻译中可以发挥重要作用。
Photothermal therapy (PTT) as a relatively new cancer treatment method has attracted worldwide attention. Previous research on PTT has focused on its therapy efficiency and selectivity. The early prognosis of PTT, which is pivotal for the assessment of the treatment and the therapy stratification, however, has been rarely studied. In the present study, we investigated diffusion-weighted magnetic resonance imaging (DW-MRI) as a tool for therapy monitoring and early prognosis of PTT. To this end, we injected PEGylated graphene oxide (GO-PEG) or iron oxide deposited graphene oxide (GO-IONP-PEG) to 4T1 tumor models and irradiated the tumors at different drug-light intervals to induce PTT. For GO-IONP-PEG injected animals, we also included therapy arms where an external magnetic field was applied to the tumors to improve the delivery of the nanoparticle transducers. DW-MRI was performed at different time points after PTT and the tumor apparent diffusion coefficients (ADCs) were analyzed and compared. Our studies show that photothermal agents, magnetic guidance, and drug-light intervals can all affect PTT treatment efficacy. Impressively, ADC value changes at early time points after PTT (less than 48 h) were found to be well-correlated with tumor growth suppression that was apparent days or weeks later. The changes were most sensitive to conditions that can extend the survival for more than 4 weeks, in which cases the 48 h ADC values were increased by more than 80%. These studies demonstrate for the first time that DW-MRI can be an accurate prognosis tool for PTT, suggesting an important role it can play in the future PTT evaluation and clinical translation of the modality.
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影响因子：
17.1
作者：
Jang, Boseung;Park, Jin-Young;Choi, Yongdoo
通讯作者：
Choi, Yongdoo
影响因子：
14
作者：
Chen, Cheng-Lung;Kuo, Ling-Ru;Chen, Yang-Yuan
通讯作者：
Chen, Yang-Yuan
影响因子：
41.2
作者：
Geim, A. K.;Novoselov, K. S.
通讯作者：
Novoselov, K. S.
影响因子：
17.1
作者：
Ghosh S;Dutta S;Gomes E;Carroll D;D'Agostino R Jr;Olson J;Guthold M;Gmeiner WH
通讯作者：
Gmeiner WH
影响因子：
14
作者：
Chertok, Beata;Moffat, Bradford A.;Yang, Victor C.
通讯作者：
Yang, Victor C.