Impaired flush response to niacin skin patch among schizophrenia patients and their nonpsychotic relatives: the effect of genetic loading.
Impaired flush response to niacin skin patch among schizophrenia patients and their nonpsychotic relatives: the effect of genetic loading.
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DOI：
10.1093/schbul/sbm153
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发表时间：
2009-01
影响因子：
6.6
通讯作者：
Chen WJ
中科院分区：
文献类型：
--
作者：
Chang SS;Liu CM;Lin SH;Hwu HG;Hwang TJ;Liu SK;Hsieh MH;Guo SC;Chen WJ
我们以前曾报道过精神分裂症患者及其非精神病亲属对烟酸皮肤贴片的潮红反应具有家族聚集性。然而，很少有人知道这种异常的皮肤反应是否与精神分裂症的遗传负荷有关。本研究比较了烟酸潮红反应的主题，只有一个成员患有精神分裂症的家庭（单纯型家庭）与家庭有一个同胞对精神分裂症（多重家庭）。受试者为精神分裂症患者及其非精神病一级亲属，来自单纯家族（176名先证者，260名父母和80名兄弟姐妹）和多重家族（311名先证者，180名父母和52名兄弟姐妹）以及94名健康对照。将3种浓度（0.001 M、0.01 M和0.1 M）的烟酸贴剂贴敷于前臂皮肤，分别在5、10和15分钟时用4分量表评定潮红反应。多发性家族的精神分裂症先证者及其亲属对烟酸的潮红反应比单纯性家族的先证者及其亲属对烟酸的潮红反应更弱，并且0.1M烟酸浓度比0.01M或0.001M烟酸浓度更能揭示这种分化。对于0.1M的最高浓度和15分钟的最长时间滞后，先证者（23%），父母（27%）和兄弟姐妹（19%）的亚组仍然表现出非潮红反应。精神分裂症患者及其来自精神分裂症遗传负荷较高的家族的亲属对烟酸皮肤贴片的潮红反应更受损，这一发现对未来精神分裂症的遗传解剖具有意义。
We previously reported familial aggregation in flush response to niacin skin patch among schizophrenia patients and their nonpsychotic relatives. However, little is known about whether this abnormal skin response is associated with genetic loading for schizophrenia. This study compared the niacin flush response in subjects from families with only one member affected with schizophrenia (simplex families) with those from families having a sib-pair with schizophrenia (multiplex families). Subjects were patients with schizophrenia and their nonpsychotic first-degree relatives from simplex families (176 probands, 260 parents, and 80 siblings) and multiplex families (311 probands, 180 parents, and 52 siblings) as well as 94 healthy controls. Niacin patches of 3 concentrations (0.001M, 0.01M, and 0.1M) were applied to forearm skin, and the flush response was rated at 5, 10, and 15 minutes, respectively, with a 4-point scale. More attenuated flush response to topical niacin was shown in schizophrenia probands and their relatives from multiplex families than in their counterparts from simplex families, and the differentiation was better revealed using 0.1M concentration of niacin than 0.01M or 0.001M. For the highest concentration of 0.1M and the longest time lag of 15 minutes, a subgroup of probands (23%), parents (27%), and siblings (19%) still exhibited nonflush response. Flush response to niacin skin patch is more impaired in schizophrenia patients and their relatives from families with higher genetic loading for schizophrenia, and this finding has implications for future genetic dissection of schizophrenia.
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影响因子：
--
作者：
Gueorguieva, R;Krystal, JH
通讯作者：
Krystal, JH
影响因子：
11.3
作者：
Bosveld-van Haandel, Linda;Knegtering, Rikus;van den Bosch, Robert J.
通讯作者：
van den Bosch, Robert J.
影响因子：
6.6
作者：
Lin, Sheng-Hsiang;Liu, Chih-Min;Chen, Wei J.
通讯作者：
Chen, Wei J.
影响因子：
4.5
作者：
LYONS, MJ;FARAONE, SV;TSUANG, MT
通讯作者：
TSUANG, MT
DOI：
10.1002/ajmg.b.20156
发表时间：
2004-05-15
影响因子：
2.8
作者：
Covault, J;Pettinati, H;Kranzler, HR
通讯作者：
Kranzler, HR