A prospective study of reticular macular disease.
A prospective study of reticular macular disease.
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DOI：
10.1016/j.ophtha.2011.01.029
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发表时间：
2011-08
期刊：
影响因子：
13.7
通讯作者：
Souied EH
中科院分区：
文献类型：
--
作者：
Pumariega NM;Smith RT;Sohrab MA;Letien V;Souied EH
在一项大型前瞻性研究中，网状假性黄斑变性（RPD）是网状黄斑疾病（RMD）的影像学表现，在患有AMD和单侧脉络膜新生血管（CNV）的受试者的高风险眼睛中，确定其进展为晚期老年性黄斑变性（AMD）的风险。队列研究。AMD患者271例；94例有RPD， 177例无RPD。我们在NAT 2研究中研究了271名AMD患者的图像，这是一项为期3年的前瞻性研究，研究对象是单侧CNV和侧眼大软性囊肿患者。另一只患晚期黄斑变性风险较高的眼睛是研究用眼。每个受试者有5次访问。每次就诊时的成像包括彩色、无红色、蓝光摄影和荧光素血管造影。在整个3年的研究中，随着疾病进展，我们分析了RPD的存在。晚期AMD （CNV或地理萎缩）的发展。在完成3年研究的271名受试者中，在任何访问时，患有RPD的眼睛的晚期AMD率（56%或53/94）明显高于未患有RPD的眼睛(32%或56/177；p = 7.7E-05， χ2检验；相对风险（RR） 1.8；95%置信区间（CI） 1.4-2.4)。患有RPD的女性患晚期AMD的几率（66%）是没有RPD的女性的两倍多（30%,p = 5.1E-06, RR 2.2, 95% CI 1.6-3.1）。据我们所知，这是对网状黄斑病（RMD）的第一个全面的前瞻性研究，RMD是AMD的一种独特的临床表型，包括RPD。该研究有力地证实，RMD是一种具有各种影像学表现的疾病实体，可能以炎症或血管为基础，与进展为晚期AMD的高风险相关。RMD值得照顾AMD患者的临床医生更广泛的认识和考虑。
To determine the risk of progression to advanced age-related macular degeneration (AMD) conferred by reticular pseudodrusen (RPD), an imaging presentation of reticular macular disease (RMD), in high-risk fellow eyes of subjects with AMD and unilateral choroidal neovascularization (CNV) in a large prospective study. Cohort study. 271 subjects with AMD; 94 with RPD and 177 without RPD. We studied images from a cohort of 271 subjects with AMD in the NAT 2 Study, a 3-year prospective study of subjects with unilateral CNV and large soft drusen in the fellow eye. The fellow eye, at high risk for developing advanced AMD, was the study eye. There were 5 visits per subject. Imaging at each visit consisted of color, red free, and blue light photography and fluorescein angiography. We analyzed the images for the presence of RPD, following disease progression throughout the 3-year study. The development of advanced AMD (CNV or geographic atrophy). For the 271 subjects who completed the full 3-year study, there was a significantly higher rate of advanced AMD (56% or 53/94) in fellow eyes with RPD at any visit compared to eyes without RPD (32% or 56/177; p = 7.7E-05, χ2 test; relative risk (RR) 1.8; 95% confidence interval (CI) 1.4–2.4). The chance of developing advanced AMD in the fellow eye in females with RPD (66%) was more than double compared to females without RPD (30%, p = 5.1E-06, RR 2.2, 95% CI 1.6–3.1). To our knowledge, this is the first comprehensive prospective study of reticular macular disease (RMD), a distinct clinical phenotype of AMD which includes RPD. It provides strong confirmation that RMD, a disease entity with stereotypical presentations across imaging modalities, is associated with high risk of progression to advanced AMD, perhaps on an inflammatory or vascular basis. RMD deserves wider recognition and consideration by clinicians caring for patients with AMD.
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影响因子：
12.7
作者：
Walsh, SJ;Rau, LM
通讯作者：
Rau, LM
影响因子：
4.2
作者：
Klein, Ronald;Meuer, Stacy M.;Klein, Barbara E. K.
通讯作者：
Klein, Barbara E. K.
DOI：
10.1097/00006982-199515030-00001
发表时间：
1995-01-01
影响因子：
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作者：
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影响因子：
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作者：
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通讯作者：
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