MIND diet and the risk of dementia: a population-based study.
MIND diet and the risk of dementia: a population-based study.
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DOI：
10.1186/s13195-022-00957-1
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发表时间：
2022-01-12
期刊：
影响因子：
--
通讯作者：
Voortman T
中科院分区：
文献类型：
--
作者：
de Crom TOE;Mooldijk SS;Ikram MK;Ikram MA;Voortman T
坚持Median-DASH神经退行性延迟干预（MIND）饮食与痴呆风险降低有关，但生活方式的反向因果关系和残留混杂可能部分解释了这种联系。我们旨在通过研究累积时间段内的相关性来解决这些问题，这可能会提供对可能的反向因果关系的洞察，并通过使用历史和更现代的饮食数据来解决这些问题，因为历史数据可能受生活方式因素的影响较小。在基于人群的鹿特丹研究中，使用1989年至1993年期间5375名参与者（基线I）和2009年至2013年期间2861名参与者（基线II）的验证食物频率问卷评估了饮食摄入量。我们计算了MIND饮食评分，并使用考克斯模型研究了其与全因痴呆风险的关系。全因痴呆事件记录到2018年。在从基线I开始的平均15.6年的随访期间，1188名参与者患上了痴呆症。在基线I时较高的MIND饮食评分与前7年随访期间痴呆风险较低相关（风险比（HR）[95%置信区间（CI）]/标准差（SD）增加，0.85 [0.74，0.98]），但随着随访时间的延长，相关性消失。从基线II开始的平均随访时间为5.9年，期间有248名参与者患上了痴呆症。在基线II时较高的MIND饮食评分与每个随访间隔内痴呆风险较低相关，但相关性随时间推移略有减弱（7年随访的HR [95%CI]每SD增加，0.76 [0.66，0.87]）。基线II时的MIND饮食评分与痴呆风险的相关性比基线I时的MIND饮食评分更强。在随访的第一年内，更好地坚持MIND饮食与痴呆症的风险降低有关，但这可能部分由反向因果关系和生活方式的残留混杂因素解释。需要进一步的研究来阐明MIND饮食可能在多大程度上影响痴呆症的风险。在线版本包含补充材料，可通过10.1186/s13195-022-00957-1获得。
Adherence to the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet has been linked to a decreased risk of dementia, but reverse causality and residual confounding by lifestyle may partly account for this link. We aimed to address these issues by studying the associations over cumulative time periods, which may provide insight into possible reverse causality, and by using both historical and more contemporary dietary data as this could give insight into confounding since historical data may be less affected by lifestyle factors. In the population-based Rotterdam Study, dietary intake was assessed using validated food frequency questionnaires in 5375 participants between 1989 and 1993 (baseline I) and in a largely non-overlapping sample in 2861 participants between 2009 and 2013 (baseline II). We calculated the MIND diet score and studied its association with the risk of all-cause dementia, using Cox models. Incident all-cause dementia was recorded until 2018. During a mean follow-up of 15.6 years from baseline I, 1188 participants developed dementia. A higher MIND diet score at baseline I was associated with a lower risk of dementia over the first 7 years of follow-up (hazard ratio (HR) [95% confidence interval (CI)] per standard deviation (SD) increase, 0.85 [0.74, 0.98]), but associations disappeared over longer follow-up intervals. The mean follow-up from baseline II was 5.9 years during which 248 participants developed dementia. A higher MIND diet score at baseline II was associated with a lower risk of dementia over every follow-up interval, but associations slightly attenuated over time (HR [95% CI] for 7 years follow-up per SD increase, 0.76 [0.66, 0.87]). The MIND diet score at baseline II was more strongly associated with the risk of dementia than the MIND diet score at baseline I. Better adherence to the MIND diet is associated with a decreased risk of dementia within the first years of follow-up, but this may in part be explained by reverse causality and residual confounding by lifestyle. Further research is needed to unravel to which extent the MIND diet may affect the risk of dementia. The online version contains supplementary material available at 10.1186/s13195-022-00957-1.
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影响因子：
11.2
作者：
Kang, JH;Ascherio, A;Grodstein, F
通讯作者：
Grodstein, F
影响因子：
14
作者：
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影响因子：
120.7
作者：
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DOI：
10.1136/bmj.k2392
发表时间：
2018-06-13
期刊：
BMJ (Clinical research ed.)
影响因子：
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作者：
Mozaffarian D;Rosenberg I;Uauy R
通讯作者：
Uauy R
DOI：
10.1016/j.jalz.2015.04.011
发表时间：
2015-09
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
Morris MC;Tangney CC;Wang Y;Sacks FM;Barnes LL;Bennett DA;Aggarwal NT
通讯作者：
Aggarwal NT