Multiple Myeloma and lifetime occupation: results from the EPILYMPH study.
Multiple Myeloma and lifetime occupation: results from the EPILYMPH study.
复制标题
多发性骨髓瘤和终生职业：Epilymph研究的结果。
DOI：
10.1186/1745-6673-7-25
复制
发表时间：
2012-12-14
期刊：
影响因子：
--
通讯作者：
Cocco P
中科院分区：
文献类型：
--
作者：
Perrotta C;Staines A;Codd M;Kleefeld S;Crowley D;T' Mannetje A;Becker N;Brennan P;De Sanjosé S;Foretova L;Maynadié M;Nieters A;Boffetta P;Cocco P
EPILYMPH研究将详细的职业暴露评估方法应用于在六个欧洲国家进行的大型多中心病例对照研究。基于EPILYMPH数据集，本文分析了多发性骨髓瘤（MM）与教育水平、终生职业史和职业暴露相关的风险。纳入了277例MM病例和每例病例4例匹配对照。对照组随机选择，年龄（+/-5岁），中心和性别匹配。通过详细的问卷调查获得了终生职业和终生接触特定工作场所制剂的情况。当地工业卫生专家评估了特定暴露的可能性和强度。计算教育水平、个体职业和特定暴露的比值比和95%置信区间（OR，95%CI）。对个人职业和暴露进行无条件logistic回归模型分析。低教育水平与MM相关，OR=1.68（95% CI 1.02-2.76）。观察到普通农民（OR=1.77; 95%CI 1.05-2.99）和清洁工人（OR=1.69; 95%CI 1.04-2.72）的风险增加，调整了教育水平。打印机的风险也升高，但不显著（OR=2.06; 95% CI 0.97-4.34）。农药暴露超过10年或更长时间会增加MM风险（OR=1.62; 95% CI 1.01-2.58）。这些结果证实了MM与农场工作的关联，并表明其与印刷和清洁的关联。虽然长期接触农药似乎是MM的一个风险因素，但无法证实与接触有机溶剂相关的过度风险。
The EPILYMPH study applied a detailed occupational exposure assessment approach to a large multi-centre case–control study conducted in six European countries. This paper analysed multiple myeloma (MM) risk associated with level of education, and lifetime occupational history and occupational exposures, based on the EPILYMPH data set. 277 MM cases and four matched controls per each case were included. Controls were randomly selected, matching for age (+/− 5 years), centre and gender. Lifetime occupations and lifetime exposure to specific workplace agents was obtained through a detailed questionnaire. Local industrial hygienists assessed likelihood and intensity for specific exposures. The odds ratio and 95% confidence intervals (OR, 95% CI) were calculated for level of education, individual occupations and specific exposures. Unconditional logistic regression models were run for individual occupations and exposures. A low level of education was associated with MM OR=1.68 (95% CI 1.02-2.76). An increased risk was observed for general farmers (OR=1.77; 95% CI 1.05-2.99) and cleaning workers (OR=1.69; 95% CI 1.04-2.72) adjusting for level of education. Risk was also elevated, although not significant, for printers (OR=2.06; 95% CI 0.97-4.34). Pesticide exposure over a period of ten years or more increased MM risk (OR=1.62; 95% CI 1.01-2.58). These results confirm an association of MM with farm work, and indicate its association with printing and cleaning. While prolonged exposure to pesticides seems to be a risk factor for MM, an excess risk associated with exposure to organic solvents could not be confirmed.
登录
查看更多内容
影响因子：
168.9
作者：
Renehan, Andrew G.;Tyson, Margaret;Zwahlen, Marcel
通讯作者：
Zwahlen, Marcel
影响因子：
20.3
作者：
Landgren, Ola;Kyle, Robert A.;Alavanja, Michael C.
通讯作者：
Alavanja, Michael C.
影响因子：
6.4
作者：
Moore, Tina;Brennan, Paul;Boffetta, Paolo
通讯作者：
Boffetta, Paolo
影响因子：
8.4
作者：
Rafnsson, Vilhjalmur
通讯作者：
Rafnsson, Vilhjalmur
影响因子：
4.9
作者：
Svec, MA;Ward, MH;De Roos, AJ
通讯作者：
De Roos, AJ