Neuromodulation in Beta-Band Power Between Movement Execution and Inhibition in the Human Hippocampus.
Neuromodulation in Beta-Band Power Between Movement Execution and Inhibition in the Human Hippocampus.
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DOI：
10.1111/ner.13486
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发表时间：
2022-03
期刊：
影响因子：
--
通讯作者：
Lee B
中科院分区：
文献类型：
--
作者：
Del Campo-Vera RM;Tang AM;Gogia AS;Chen KH;Sebastian R;Gilbert ZD;Nune G;Liu CY;Kellis S;Lee B
海马体被认为与运动有关，但它在运动执行和抑制中的确切作用还没有得到很好的研究。先前的直接神经记录工作已经发现β-波段（13-30 Hz）调制在整个运动系统的运动执行和抑制中，但是在运动抑制期间海马中β-波段调制的作用还没有很好地理解。在这里，我们进行了一个去/不去达到的任务，在10例难治性癫痫患者研究人类海马β功率的变化在运动过程中。10名癫痫患者（5名女性;年龄21-46岁）植入了颅内深部电极，用于癫痫发作监测和定位。在进行/不进行运动任务期间，以2000 Hz对局部场电位进行采样。使用Wilcoxon符号秩假设检验对每例患者进行Go和No-Go条件之间的β波段功率比较。进行子分析以评估前后接触、同侧与对侧接触以及男性与女性β屈光度值的差异。与基线相比，10名患者中有8名在Go运动反应期间显示出显著的β功率降低（p < 0.05）。十名患者中有八名在没有运动的情况下，在No-Go条件下也表现出显著的β功率增加。同侧与对侧接触之间没有显著差异，前海马与后海马接触也没有显著差异。女性参与者的任务成功率高于男性，并且在No-Go条件下β功率的增加显着更大（p < 0.001）。这些发现表明，海马β功率的增加与运动抑制有关。据我们所知，这项研究是第一次在人类海马体中报告这种现象。β带可以表示涉及运动处理的状态变化信号。未来关注β波段对理解人类运动和冲动控制将是至关重要的。
The hippocampus is thought to be involved in movement, but its precise role in movement execution and inhibition has not been well studied. Previous work with direct neural recordings has found beta-band (13–30 Hz) modulation in both movement execution and inhibition throughout the motor system, but the role of beta-band modulation in the hippocampus during movement inhibition is not well understood. Here we perform a Go/No-Go reaching task in ten patients with medically-refractory epilepsy to study human hippocampal beta-power changes during movement. Ten epilepsy patients (5 female; ages 21–46) were implanted with intracranial depth electrodes for seizure monitoring and localization. Local field potentials were sampled at 2000 Hz during a Go/No-Go movement task. Comparison of beta band power between Go and No-Go conditions was conducted using Wilcoxon signed-rank hypothesis testing for each patient. Sub-analyses were conducted to assess differences in the anterior versus posterior contacts, ipsilateral versus contralateral contacts, and male versus female beta power values. Eight out of ten patients showed significant beta power decreases during the Go movement response (p < 0.05) compared to baseline. Eight out of ten patients also showed significant beta power increases in the No-Go condition, occurring in the absence of movement. No significant differences were noted between ipsilateral versus contralateral contacts, nor in anterior versus posterior hippocampal contacts. Female participants had a higher task success rate than males and had significantly greater beta-power increases in the No-Go condition (p < 0.001). These findings indicate that increases in hippocampal beta power are associated with movement inhibition. To our knowledge, this study is the first to report this phenomenon in the human hippocampus. The beta band may represent a state-change signal involved in motor processing. Future focus on the beta band in understanding human motor and impulse control will be vital.
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