The cell biology of synaptic plasticity.

The cell biology of synaptic plasticity.
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DOI:
10.1126/science.1209236
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发表时间:
2011-11-04
期刊:
Science (New York, N.Y.)
影响因子:
--
通讯作者:
Martin KC
Martin KC
中科院分区:
其他
文献类型:
--
作者:
Ho VM;Lee JA;Martin KC

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突触可塑性是神经元之间连接的经验依赖性变化,被认为是学习和记忆的基础。在这里,我们讨论了当神经元对外部刺激做出反应时,细胞和分子过程发生变化,以及这些变化如何导致突触连接的增加或减少。突触成分的修饰和基因表达的改变是许多形式的可塑性所必需的。我们专注于兴奋性神经元在哺乳动物海马,学习相关的可塑性的最好的研究模型系统之一。
Synaptic plasticity is the experience-dependent change in connectivity between neurons that is believed to underlie learning and memory. Here, we discuss the cellular and molecular processes that are altered when a neuron responds to external stimuli, and how these alterations lead to an increase or decrease in synaptic connectivity. Modification of synaptic components and changes in gene expression are necessary for many forms of plasticity. We focus on excitatory neurons in the mammalian hippocampus, one of the best-studied model systems of learning-related plasticity.
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