Entanglement-Based Thermoplastic Shape Memory Polymeric Particles with Photothermal Actuation for Biomedical Applications.
Entanglement-Based Thermoplastic Shape Memory Polymeric Particles with Photothermal Actuation for Biomedical Applications.
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DOI：
10.1021/acsami.8b01582
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发表时间：
2018-04-25
影响因子：
9.5
通讯作者：
Green JJ
中科院分区：
文献类型：
--
作者：
Guo Q;Bishop CJ;Meyer RA;Wilson DR;Olasov L;Schlesinger DE;Mather PT;Spicer JB;Elisseeff JH;Green JJ
在临床高热温度下触发形状记忆功能可以使得能够在临床实践中控制和致动形状记忆系统。为此，我们开发了光诱导的形状记忆微粒组成的聚（D，L-乳酸）（PDLLA）矩阵封装金纳米粒子（Au@PDLLA混合微粒）。该形状记忆聚合物体系首次证明了在体温下保持各向异性形状的能力，在高于体温的窄温度范围内触发形状记忆效应，以适当的形状恢复速度（37 °C < T < 45 °C）恢复到球形。我们采用了一种改进的薄膜拉伸加工方法，仔细控制拉伸温度，使这些微米级颗粒的形状记忆和各向异性。因此，我们在小型化形状记忆系统中实现了纯粹基于缠结的形状记忆响应而没有化学交联。此外，这些形状记忆微粒表现出光诱导的时空控制其形状恢复使用激光触发光热加热掺杂的金纳米粒子。这种形状记忆系统由生物相容性组件组成，并表现出其性质的时空可控性，显示出各种生物医学应用的潜力，如本研究中所示的调节巨噬细胞吞噬作用。
Triggering shape memory functionality under clinical hyperthermia temperatures could enable the control and actuation of shape memory systems in clinical practice. For this purpose, we developed light-inducible shape memory microparticles composed of a poly (D,L-lactic acid) (PDLLA) matrix encapsulating gold nanoparticles (Au@PDLLA hybrid microparticles). This shape memory polymeric system for the first time demonstrates the capability of maintaining an anisotropic shape at body temperature with triggered shape memory effect back to a spherical shape at a narrow temperature range above body temperature with a proper shape recovery speed (37 °C < T < 45 °C). We applied a modified film-stretching processing method with carefully controlled stretching temperature to enable shape memory and anisotropy in these micron-sized particles. Accordingly, we achieved purely entanglement-based shape memory response without chemical crosslinks in the miniaturized shape memory system. Furthermore, these shape memory microparticles exhibited light-induced spatiotemporal control of their shape recovery using a laser to trigger photothermal heating of doped gold nanoparticles. This shape memory system is composed of biocompatible components and exhibits spatiotemporal controllability of its properties, demonstrating potential for various biomedical applications, such as tuning macrophage phagocytosis as demonstrated in this study.
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影响因子：
17.3
作者：
Meyer RA;Sunshine JC;Green JJ
通讯作者：
Green JJ
影响因子：
10
作者：
Hearon K;Wierzbicki MA;Nash LD;Landsman TL;Laramy C;Lonnecker AT;Gibbons MC;Ur S;Cardinal KO;Wilson TS;Wooley KL;Maitland DJ
通讯作者：
Maitland DJ
影响因子：
29.4
作者：
Le, Duy M.;Kulangara, Karina;Adler, Andrew F.;Leong, Kam W.;Ashby, Valerie Sheares
通讯作者：
Ashby, Valerie Sheares
DOI：
10.1073/pnas.1308345110
发表时间：
2013-06-25
影响因子：
11.1
作者：
Kolhar, Poornima;Anselmo, Aaron C.;Mitragotri, Samir
通讯作者：
Mitragotri, Samir
影响因子：
2.4
作者：
HO, CC;KELLER, A;OTTEWILL, RH
通讯作者：
OTTEWILL, RH