Pacing across the membrane: the novel PACE family of efflux pumps is widespread in Gram-negative pathogens.
Pacing across the membrane: the novel PACE family of efflux pumps is widespread in Gram-negative pathogens.
复制标题
DOI：
10.1016/j.resmic.2018.01.001
复制
发表时间：
2018-09
影响因子：
2.6
通讯作者：
Paulsen IT
中科院分区：
文献类型：
--
作者：
Hassan KA;Liu Q;Elbourne LDH;Ahmad I;Sharples D;Naidu V;Chan CL;Li L;Harborne SPD;Pokhrel A;Postis VLG;Goldman A;Henderson PJF;Paulsen IT
蛋白细菌抗菌化合物外排（PACE）转运蛋白家族最近才被描述。PACE家族转运蛋白可赋予对用作消毒剂和防腐剂的一系列杀生物剂的抗性，并且由许多重要的革兰氏阴性人类病原体编码。然而，我们才刚刚开始了解这些蛋白质的功能范围和转运机制。编码PACE家族蛋白的基因通常在细菌物种的核心基因组中保守，而不是在最近获得的移动的遗传元件上保守，这表明它们赋予除杀生物剂抗性之外的重要核心功能。PACE家族蛋白的三维结构信息尚不可用。然而，PACE蛋白具有几个非常高度保守的氨基酸序列基序，这些基序可能对底物转运很重要。PACE蛋白在其N-和C-末端的一半之间也显示出很强的氨基酸序列保守性，这表明它们是通过由两个跨膜螺旋组成的祖先蛋白的复制而进化的。鉴于它们在革兰氏阴性病原体中的耐药性功能，PACE蛋白应该是未来详细研究的主题。
The proteobacterial antimicrobial compound efflux (PACE) family of transport proteins was only recently described. PACE family transport proteins can confer resistance to a range of biocides used as disinfectants and antiseptics, and are encoded by many important Gram-negative human pathogens. However, we are only just beginning to appreciate the range of functions and the mechanism(s) of transport operating in these proteins. Genes encoding PACE family proteins are typically conserved in the core genomes of bacterial species rather than on recently acquired mobile genetic elements, suggesting that they confer important core functions in addition to biocide resistance. Three-dimensional structural information is not yet available for PACE family proteins. However, PACE proteins have several very highly conserved amino acid sequence motifs that are likely to be important for substrate transport. PACE proteins also display strong amino acid sequence conservation between their N— and C-terminal halves, suggesting that they evolved by duplication of an ancestral protein comprised of two transmembrane helices. In light of their drug resistance functions in Gram-negative pathogens, PACE proteins should be the subject of detailed future investigation.
登录
查看更多内容
影响因子：
8.8
作者：
Su CC;Bolla JR;Kumar N;Radhakrishnan A;Long F;Delmar JA;Chou TH;Rajashankar KR;Shafer WM;Yu EW
通讯作者：
Yu EW
影响因子：
11.4
作者：
Nde, Chantal W.;Jang, Hyeung-Jin;Bentley, William E.
通讯作者：
Bentley, William E.
DOI：
10.1073/pnas.1317052110
发表时间：
2013-12-10
影响因子：
11.1
作者：
Hassan, Karl A.;Jackson, Scott M.;Paulsen, Ian. T.
通讯作者：
Paulsen, Ian. T.
影响因子：
6.4
作者：
Blair JM;Piddock LJ
通讯作者：
Piddock LJ
影响因子：
16
作者：
Fluman N;Ryan CM;Whitelegge JP;Bibi E
通讯作者：
Bibi E