Incidence of ossification of the spinal ligaments in acromegaly patients.
Incidence of ossification of the spinal ligaments in acromegaly patients.
复制标题
肢端肥大患者脊柱韧带的骨化发生率。
DOI：
10.1016/j.bonr.2022.101628
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发表时间：
2022-12
期刊：
影响因子：
2.5
通讯作者：
Ito, Nobuaki
中科院分区：
文献类型：
--
作者：
Hoshino, Yoshitomo;Hidaka, Naoko;Kato, Hajime;Koga, Minae;Taniguchi, Yuki;Kobayashi, Hiroshi;Nangaku, Masaomi;Makita, Noriko;Ito, Nobuaki
关键词：
一些先前的病例报告暗示肢端肥大症和脊柱韧带骨化之间的关系。然而，还没有关于肢端肥大症患者脊柱韧带骨化发生率的病例系列报道。为此，在本研究中，连续10例肢端肥大症患者的脊柱计算机断层扫描（CT）进行了检查。10例患者中有5例出现脊柱韧带骨化。其中，2例患者发生后纵韧带骨化（OPLL），明显高于一般成人人群中OPLL的患病率（1.9- 4.3%）。脊柱韧带骨化组的体重指数显著较高（p = 0.03），但在年龄、性别、血清磷酸盐、白蛋白调整钙、生长激素（GH）、胰岛素样生长因子-1（IGF-1）标准差或糖尿病发病率方面，脊柱韧带骨化组与非骨化组之间无显著差异。骨化指数（OS指数）用于确定脊柱韧带骨化的严重程度，OS指数与GH或IGF-1之间无显著相关性（分别为p = 0.51和0.75）。这项研究首次报道了肢端肥大症患者脊柱骨化的高患病率。总之，这项研究表明肢端肥大症和脊柱韧带骨化之间可能存在联系，尽管患者数量不足以得出结论。肢端肥大症患者应进行测试，以确认或排除，脊柱骨化，并进一步研究，以澄清肢端肥大症患者脊柱骨化的潜在机制是必要的。
Some previous case reports have implied a relationship between acromegaly and ossification of the spinal ligaments. However, there have been no reports of a case series exploring the incidence of ossification of the spinal ligaments in patients with acromegaly. To this end, computed tomography (CT) of the spine in 10 consecutive patients with acromegaly was examined in this study. Five out of 10 patients had ossification of the spinal ligaments. Among them, two patients had ossification of the posterior longitudinal ligament (OPLL), which was noticeably higher than the prevalence of OPLL in the general adult population (1.9–4.3 %). Body mass index was significantly higher in the group with spinal ligament ossification (p = 0.03), but there were no significant differences in age, sex, serum phosphate, albumin-adjusted calcium, growth hormone (GH), standard deviation of insulin-like growth factor-1 (IGF-1), or the incidence of diabetes mellitus between the groups with or without ossification of the spinal ligaments. The ossification index (OS index) was used to determine the severity of spinal ligament ossification, and there were no significant correlations between the OS index and GH or IGF-1 (p = 0.51 and 0.75, respectively). This study was the first to report a high prevalence of spinal ossification in patients with acromegaly. In conclusion, this study suggested a possible association between acromegaly and ossification of the spinal ligaments, although the number of patients was insufficient to draw a conclusion. Acromegaly patients should be tested to confirm, or rule out, spinal ossification, and further studies to clarify the underlying mechanism of spinal ossification in acromegaly patients are warranted.
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DOI：
10.1002/jbmr.4550
发表时间：
2022-06
期刊：
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
影响因子：
--
作者：
通讯作者：
--
影响因子：
4.5
作者：
Kim, Sang-Il;Ha, Kee-Yong;Kim, Young-Hoon
通讯作者：
Kim, Young-Hoon
影响因子：
3
作者：
Kobashi, G;Washio, M;Tanaka, H
通讯作者：
Tanaka, H
影响因子：
5.8
作者：
Scarpa, R;De Brasi, D;Colao, A
通讯作者：
Colao, A
影响因子：
2.3
作者：
Kamakura D;Fukutake K;Nakamura K;Tsuge S;Hasegawa K;Tochigi N;Wada A;Mikami T;Takahashi H
通讯作者：
Takahashi H