Muscle-fat MRI: 1.5 Tesla and 3.0 Tesla versus histology.
Muscle-fat MRI: 1.5 Tesla and 3.0 Tesla versus histology.
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DOI：
10.1002/mus.24255
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发表时间：
2014-08
期刊：
影响因子：
3.4
通讯作者：
Elliott JM
中科院分区：
文献类型：
--
作者：
Smith AC;Parrish TB;Abbott R;Hoggarth MA;Mendoza K;Chen YF;Elliott JM
我们评估了在1.5特斯拉（T）和3.0 T扫描仪强度下使用MR成像技术测量的肌肉/脂肪分数（MFF）的准确性和可靠性，使用活检作为参考。在1.5 T和3.0 T下对猪和兔种属（n = 8）的肌肉样本进行MRI。使用基于化学位移的2点狄克逊方法，收集肌肉样品的脂肪/水的同相和异相数据。将数值与根据组织学计算的MFF进行比较。对于任何测试的肌肉，在1.5和3.0 T之间（P值= 0.41 - 0.96）或组织学和成像之间（P = 0.83）没有发现显著差异。结果表明，2点狄克逊脂肪/水分离MRI技术可在不同动物种属的不同场强下提供MFF的可靠定量，并与活检建立一致性。该结果为更大规模的量化神经肌肉疾病中肌肉脂肪的研究奠定了基础。
We evaluated muscle/fat fraction (MFF) accuracy and reliability measured with an MR imaging technique at 1.5 Tesla (T) and 3.0 T scanner strengths, using biopsy as reference. MRI was performed on muscle samples from pig and rabbit species (n = 8) at 1.5 T and 3.0 T. A chemical shift based 2-point Dixon method was used, collecting in-phase and out-of-phase data for fat/water of muscle samples. Values were compared to MFFs calculated from histology. No significant difference was found between 1.5 and 3.0 T (P values = 0.41 – 0.96), or between histology and imaging (P = 0.83) for any muscle tested. Results suggest that a 2-point Dixon fat/water separation MRI technique may provide reliable quantification of MFFs at varying field strengths across different animal species, and consistency was established with biopsy. The results set a foundation for larger scale investigation of quantifying muscle-fat in neuromuscular disorders.
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作者：
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