Impact of dust from multiple microenvironments and diet on PentaBDE body burden.

Impact of dust from multiple microenvironments and diet on PentaBDE body burden.
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DOI:
10.1021/es203314e
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发表时间:
2012-01-17
影响因子:
11.4
通讯作者:
Webster, Thomas F.
Webster, Thomas F.
中科院分区:
环境科学与生态学1区
文献类型:
--
作者:
Watkins, Deborah J.;McClean, Michael D.;Fraser, Alicia J.;Weinberg, Janice;Stapleton, Heather M.;Sjoedin, Andreas;Webster, Thomas F.

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我们的目标是确定饮食和来自多种微环境的粉尘暴露对五溴二苯醚身体负荷的相对贡献,并探索手巾作为个人暴露于五溴二苯醚的衡量标准的作用。我们进行了食物频率问卷调查,并收集了31名参与者的血清、粉尘(办公室、主要生活区、卧室和车辆)和手擦样本。办公环境中手巾中的Σ五溴联苯醚(BDE28/33、47、99、100和153的总和)与办公室(r=0.35,p=0.06)和卧室(r=0.39,p=0.04)中的粉尘呈弱相关,而与主要生活区(r=−0.05,p=0.77)或车辆(r=0.17,p=0.47)中的粉尘无关。血清Σ五溴二苯醚与居室和居室粉尘呈正相关(r=0.42p=0.02,r=0.49,p=0.008),与办公室粉尘(r=0.22,p=0.25)和车辆粉尘(r=0.20,p=0.41)无相关性。我们最终的回归模型包括了主要生活区粉尘和手巾的变量,并预测了血清Σ五溴二苯醚浓度变化的55%(p=0.0004)。饮食变量不是血清中Σ五溴二苯醚的显著预测因子。我们的研究表明,家庭环境中的粉尘暴露可能是预测北美地区五溴二苯醚身体负担的最重要因素,潜在的暴露途径可能涉及手中多溴二苯醚的残留。
Our objectives were to determine relative contributions of diet and dust exposure from multiple microenvironments to PentaBDE body burden, and to explore the role of handwipes as a measure of personal exposure to PentaBDE. We administered a food frequency questionnaire and collected serum, dust (office, main living area, bedroom, and vehicle) and handwipe samples from 31 participants. ΣPentaBDEs (sum of BDE 28/33, 47, 99, 100, and 153) in handwipes collected in the office environment were weakly correlated with dust collected from offices (r=0.35, p=0.06) and bedrooms (r=0.39, p=0.04), but not with dust from main living areas (r=−0.05, p=0.77) or vehicles (r=0.17, p=0.47). ΣPentaBDEs in serum were correlated with dust from main living areas (r=0.42, p=0.02) and bedrooms (r=0.49, p=0.008), but not with dust from offices (r=0.22, p=0.25) or vehicles (r=0.20, p=0.41). Our final regression model included variables for main living area dust and handwipes, and predicted 55% of the variation in serum ΣPentaBDE concentrations (p=0.0004). Diet variables were not significant predictors of ΣPentaBDEs in serum. Our research suggests that exposure to dust in the home environment may be the most important factor in predicting PentaBDE body burden in North Americans, and potential exposure pathways may involve PBDE residues on hands.
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