HD-tDCS as a neurorehabilitation technique for a case of post-anoxic leukoencephalopathy.
HD-tDCS as a neurorehabilitation technique for a case of post-anoxic leukoencephalopathy.
复制标题
HD-tDCS作为缺氧后白质脑病病例的神经康复技术。
DOI：
10.1080/09602011.2020.1845749
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发表时间：
2022-07
影响因子：
2.7
通讯作者：
Hampstead BM
中科院分区：
文献类型：
--
作者：
Garcia S;Hampstead BM
Post-anoxic leukoencephalopathy is a rare event that causes global demyelination secondary to anoxic injury. Given the nature and extent of the damage, cognitive and functional deficits are typically chronic even after standard therapies. Here, we describe a novel treatment approach that used high definition transcranial direct-current stimulation (HD-tDCS) with a 62-year-old male who was 5 years post-anoxic leukoencephalopathy secondary to an accidental drug overdose. HD-tDCS was administered over the left lateral prefrontal cortex across 29 daily sessions at 2 mA (20 minutes/session) in order to address dysexecutive behaviors. Results demonstrated improved delayed memory and trends for improved visuospatial and semantic fluency performance as well as improved insight and daily functioning, all of which returned to baseline by the end of a 10 week no-contact follow up period. Resting state fMRI connectivity results mirrored these changes by showing increased dorsal attention and cingulo-opercular but reduced ventral attention network connectivity after session 29, all of which returned to baseline at follow-up. These findings suggest HD-tDCS may benefit functioning even following serious and pervasive anoxic injury. Findings also suggest the need for continued HD-tDCS for maintenance purposes, though future work is needed to identify optimal dose-response information.
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DOI：
10.1097/phm.0b013e3181a0e4cb
发表时间：
2009-05-01
影响因子：
3
作者：
Jo, Jung Mi;Kim, Yun-Hee;Lee, Kwang Ho
通讯作者：
Lee, Kwang Ho
影响因子：
3.2
作者：
Au, Jacky;Katz, Benjamin;Jonides, John
通讯作者：
Jonides, John
影响因子：
7.7
作者：
Hampstead, Benjamin M.;Brown, Gregory S.;Hartley, Justin F.
通讯作者：
Hartley, Justin F.
影响因子：
1.8
作者：
Heinz UE;Rollnik JD
通讯作者：
Rollnik JD
影响因子：
2.5
作者：
Krishnamurthy, Venkatagiri;Gopinath, Kaundinya;Hampstead, Benjamin M.
通讯作者：
Hampstead, Benjamin M.